- 2E7 (See other available formats)
- Regulatory Status
- Other Names
- Integrin αIEL chain, Integrin αE chain, αE integrin, ITGAE
- Armenian Hamster IgG
- Ave. Rating
- Submit a Review
- Product Citations
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CD103 is a type I transmembrane glycoprotein known as αE integrin or Integrin αIEL chain. It belongs to the integrin family and is primarily found on intestinal intraepithelial lymphocytes (IEL). CD103 is also expressed on a subpopulation of lamina propria T cells, epithelial dendritic cells, lamina propria-derived dendritic cells, and a small subset of peripheral lymphocytes. T regulatory cells express high level of CD103. The CD103 expression on lymphocytes can be induced upon activation and TGF-β stimulation. In association with integrin β7, CD103 is expressed as αE/β7 heterodimer. Mature CD103 protein can be cleaved into 2 chains, a 150 kD (C-terminal) chain and a 25 kD (N-terminal) chain, which remain linked by disulfide bonds. CD103 binds to E-cadherin and mediates homing of lymphocytes to the intestinal epithelium.Product Details
- Verified Reactivity
- Antibody Type
- Host Species
- Armenian Hamster
- Mouse intestinal intraepithelial lymphocytes
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 488 under optimal conditions.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
* Alexa Fluor® 488 has a maximum emission of 519 nm when it is excited at 488 nm.
Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.
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- Excitation Laser
Blue Laser (488 nm)
- Application Notes
Additional reported applications (for the relevant formats) include: immunoprecipitation1, immunohistochemical staining1,7 of acetone-fixed frozen sections, immunofluorescence2, and in vitro activation1.
(PubMed link indicates BioLegend citation)
- LeFrancois L, et. al, 1994. Eur. J. Immunol. 24:635. (FC, IHC, IP)
- Mysorekar IU, et. al, 2002. J. Biol. Chem. 277:37811. (FC, IF)
- Mikami N, et al. 2011. J. Immunol. 186:6886. PubMed
- del Rio ML, et al. 2011. Transpl. Int. 24:501. (FC) PubMed
- Quinn KM, et al. 2013. J. Immunol. 191:5085. PubMed
- Verhagen J and Wraith DC. 2014. J. Immunol. Methods. S0022. (FC) PubMed
- Xiao B, et al. 2015. PLoS One 1:e0115333. (IHC)
- Product Citations
AB_535949 (BioLegend Cat. No. 121407)
AB_535950 (BioLegend Cat. No. 121408)
- Type I transmembrane glycoprotein, Integrin family, can be cleaved into 150 kD and 25 kD chains, associated with β7 integrin
Majority of intestinal intraepithelial lymphocytes (IEL), subpopulation of lamina propria T cells, epithelial dendritic cells, small subset of peripheral lymphocytes, Treg cells.
- Retention and activation of CD103+ lymphocytes in the intestinal epithelium, regulate tissue-specific T cell homing.
- Cell Type
- Dendritic cells, Lymphocytes, T cells, Tregs
- Biology Area
- Molecular Family
- Adhesion Molecules, CD Molecules
- Antigen References
1. Kilshaw PJ and SJ. Murant. 1990. Eur. J. Immunol. 20:2201.
2. Karecla PI, et al. 1995. Eur. J. Immunol. 25:852.
3. LeFrancois L, et al. 1994. Eur. J. Immunol. 24:635.
4. Sung SS, et al. 2006. J. Immunol. 176:2161.
5. Johansson-Lindbom B, et al. 2005. J. Exp. Med. 202:1063.
6. Dujardin HC, et al. 2004. Proc. Natl. Acad. Sci. USA. 101:14473.
- Gene ID
- 16407 View all products for this Gene ID
- View information about CD103 on UniProt.org
|Purified anti-mouse CD103||2E7||FC, IHC-F, IP|
|Biotin anti-mouse CD103||2E7||FC|
|PE anti-mouse CD103||2E7||FC|
|Alexa Fluor® 488 anti-mouse CD103||2E7||FC|
|Alexa Fluor® 647 anti-mouse CD103||2E7||FC|
|Alexa Fluor® 594 anti-mouse CD103||2E7||IHC-F|
|Brilliant Violet 510™ anti-mouse CD103||2E7||FC|
|APC anti-mouse CD103||2E7||FC|
|PerCP/Cyanine5.5 anti-mouse CD103||2E7||FC|
|Pacific Blue™ anti-mouse CD103||2E7||FC|
|FITC anti-mouse CD103||2E7||FC|
|Brilliant Violet 421™ anti-mouse CD103||2E7||FC|
|PE/Cyanine7 anti-mouse CD103||2E7||FC|
|APC/Cyanine7 anti-mouse CD103||2E7||FC|
|PE/Dazzle™ 594 anti-mouse CD103||2E7||FC|
|Brilliant Violet 605™ anti-mouse CD103||2E7||FC|
|Brilliant Violet 711™ anti-mouse CD103||2E7||FC|
|TotalSeq™-A0201 anti-mouse CD103||2E7||PG|
|Brilliant Violet 785™ anti-mouse CD103||2E7||FC|
|Alexa Fluor® 700 anti-mouse CD103||2E7||FC|
|TotalSeq™-C0201 anti-mouse CD103||2E7||PG|
|TotalSeq™-B0201 anti-mouse CD103||2E7||PG|
|PE/Cyanine5 anti-mouse CD103||2E7||FC|
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Purified anti-mouse CD103
Biotin anti-mouse CD103
PE anti-mouse CD103
Alexa Fluor® 488 anti-mouse CD103
Alexa Fluor® 647 anti-mouse CD103
Alexa Fluor® 594 anti-mouse CD103
Brilliant Violet 510™ anti-mouse CD103
APC anti-mouse CD103
PerCP/Cyanine5.5 anti-mouse CD103
Pacific Blue™ anti-mouse CD103
FITC anti-mouse CD103
Brilliant Violet 421™ anti-mouse CD103
PE/Cyanine7 anti-mouse CD103
APC/Cyanine7 anti-mouse CD103
PE/Dazzle™ 594 anti-mouse CD103
Brilliant Violet 605™ anti-mouse CD103
Brilliant Violet 711™ anti-mouse CD103
TotalSeq™-A0201 anti-mouse CD103
Brilliant Violet 785™ anti-mouse CD103
Alexa Fluor® 700 anti-mouse CD103
TotalSeq™-C0201 anti-mouse CD103
TotalSeq™-B0201 anti-mouse CD103
PE/Cyanine5 anti-mouse CD103