We're pleased to announce our newest product line for functionally-validated bulk purified antibodies: GoInVivo™. For researchers interested in no-hassle bulk quantities of biofunctional antibodies for mouse injection or human ex vivo studies, GoInVivo™ provides the best solution at exceptional prices.

GoInVivo™ products focus on targeting immune checkpoints. Tumor cells can express high levels of these checkpoint receptors, shutting down immune responses and taking advantage of the lack of inflammation. Learn more about these interactions with our Immunotherapy Webpage.
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GoInVivo™ features

  • Flow cytometry quality testing
  • Super low endotoxin, ≤ 1.0 EU/mg
  • Low aggregation, < 3%
  • Pathogen-free
  • Bulk sizing (5 mg, 25 mg, 50 mg, 100 mg, 500 mg, 1 g sizes)
  • Concentration between 1 mg/ml and 3 mg/ml
  • Custom sizes available
  • Sodium azide and preservative-free
In addition, some of our antibodies are validated in functional assays, including anti-human PD-1 (clone EH12.2H7). All GoInVivo™ reagents will be validated by functional assays.
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Anti-human PD-1 inhibits the binding of PD-L1. The graphs show two sets of data. First, recombinant human PD-L1-Fc binds to immobilized human PD-1-Fc that has been coated overnight on a 96-well plate (Cyan lines). PD-1-Fc was coated at 1 µg/mL, and increasing concentrations of PD-L1-Fc (cyan diamonds) or paired PBS wells (cyan circles) were incubated overnight. The bound recombinant PD-L1-Fc was detected using biotin anti-human PD-L1 and Avidin HRP, followed by TMB. After verifying that PD-L1-Fc binds to immobilized PD-1-Fc, a second experiment was performed in which the coated PD-1-Fc was pre-incubated with increasing concentrations of anti-human PD-1 (clone EH12.2H7, purple squares) or isotype control (clone MOPC-21, purple circles), followed by incubation with a fixed concentration of PD-L1 (1 µg/mL). Clone EH12.2H7 inhibits PD-1/PD-L1 interaction in a dose dependent manner.

GoInVivo™ products are tested to be free of the following pathogens based on the origin of the antibody. Pathogen-free is defined based on IDEXX BioResearch’s IMPACT test (PCR-based screening). For detailed information regarding the sensitivity of the assays please contact BioLegend Technical Service: tech@biolegend.com

Mouse Antibodies

Mycoplasma spp.
Mycoplasma pulmonis
Sendai virus
Mouse hepatitis virus
Pneumonia virus of mice
Minute virus of mice
Mouse parvovirus (MPV1-5)
Theiler's murine encephalomyelitis virus
Murine norovirus
Reovirus 3
Mouse rotavirus
Ectromelia virus
Lymphocytic choriomeningitis virus
Polyoma virus
Lactate dehydrogenase-elevating virus
Mouse adenovirus (MAD1, MAD2)
Mouse cytomegalovirus
K virus
Mouse thymic virus
Hantaan virus

Rat Antibodies

Mycoplasma spp.
Mycoplasma pulmonis
Pneumonia virus of mice
Kilham's rat virus
Toolan's H1 virus
Rat parvovirus
Lymphocytic choriomeningitis virus
Rat cytomegalovirus
Sendai virus
Rat coronavirus
Sialodacryoadenitis virus
Rat minute virus
Seoul virus
Mouse adenovirus
Reovirus 3
Rat theilovirus

Hamster Antibodies

Mycoplasma spp.
Mycoplasma pulmonis
Pneumonia virus of mice
Kilham's rat virus
Toolan's H1 virus
Hamster parvovirus
Lymphocytic choriomeningitis virus
Minute virus of mice
Theiler's murine encephalomyelitis virus
Sendai virus
Reovirus 3
Hantaan virus
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