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| The complement system (CS) plays an essential role in innate and adaptive immune response. Increasing evidence suggests that deregulation of the complement cascade is a contributing factor leading to chronic inflammation and neurodegeneration observed in Alzheimer’s disease (AD). Localization of a full range of complement proteins from C1q to C5b-9 (membrane attack complex, MAC) with amyloid deposits is a prominent feature of AD lesions. Notably, mRNA levels of complement components are upregulated in the affected regions of AD brains. Research has shown that amyloid-beta (Aβ) aggregates can initiate antibody-independent complement activation by binding to C1q and C3b. Furthermore, Aβ deposits are frequently surrounded by activated microglia and reactive astrocytes which are capable of producing complement proteins as well as phagocytosing and degrading Aβ. These inflammatory responses appear to initially play a protective role by removing Aβ deposits. However, the continuous generation of Aβ aggregates leads to persistent complement activation and sustained inflammation that is detrimental to neurons in the brain. |
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| BioLegend is proud to offer a variety of antibodies for complement detection provided in multiple formats for use in different applications. |
Related Products |
| Antibodies to Complement Proteins |
| Description | Clone | Reactivity | Cat. No. |
|---|---|---|---|
| Purified anti-complement C3b/iC3b Antibody | 3E7/C3b | Human, Non-Human Primate | 846102 |
| Purified anti-complement C3/C3b/iC3b Antibody | 6C9/C3b | Human | 846502 |
| Purified anti-complement C3/C3b/iC3b Antibody | 7C12/C3b | Human | 846402 |
| Purified anti-complement C3/C3b/iC3b/C3d Antibody | 1H8/C3b | Human | 846302 |
| Purified anti-human C3a/C3a(desArg)/C3 Antibody | K13/16 | Human | 518101 518102 |
| LEAF™ Purified anti-human C3a/C3a(desArg)/C3 Antibody | K13/16 | Human | 518103 518104 |
| Biotin anti-human C3a/C3a(desArg)/C3 Antibody | D17/1 | Human | 518001 518002 |
| Biotin anti-human C5a/C5a(desArg)/C5 Antibody | G25/2 | Human | 518305 518306 |
| Antibodies to Complement Receptors |
| Description | Clone | Reactivity | Cat. No. |
|---|---|---|---|
| Alexa Fluor® 488 anti-rat CD11b/c Antibody | OX-42 | Rat | 201812 |
| Alexa Fluor® 647 anti-rat CD11b/c Antibody | OX-42 | Rat | 201814 |
| Purified anti-CD21 (Complement receptor 2) Antibody | Bu32 | Human | 354902 |
| Biotin anti-CD21 (Complement receptor 2) Antibody | Bu32 | Human | 354913 |
| Purified anti-CD35 (Complement receptor 1) Antibody | E11 | Human | 333402 |
| Purified anti-CD46 (MCP) Antibody | TRA-2-10 | Human | 352403 352404 |
| Anti-CD93 (Cq1 receptor) Antibody | 60.11 | Human, Mouse, Rat | 920701 |
| Anti-CD93 (Cq1 receptor) Antibody | 74.5.2 | Human, Mouse, Rat | 920601 |
Featured Products |
| Antibodies to Complement-Related Proteins |
| Description |
|---|
| Purified anti-human Factor H Antibody |
| Biotin anti-human Factor H Antibody |
| LEGEND MAX™ Human Factor H ELISA Kit with Pre-coated Plates |
| Alexa Fluor® 647 anti-mouse CD55 (DAF) Antibody |
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