- QA18A37 (See other available formats)
- Regulatory Status
- Other Names
- T8, Leu2
- Mouse IgG1, κ
- Ave. Rating
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- Product Citations
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CD8a is a 32-34 kD type I glycoprotein. It forms a homodimer (CD8a/a) or heterodimer (CD8a/b) with CD8b. CD8, also known as T8 and Leu2, is a member of the immunoglobulin superfamily found on the majority of thymocytes, a subset of peripheral blood T cells, and NK cells (which express almost exclusively CD8a homodimers). CD8 acts as a co-receptor with MHC class I-restricted T cell receptors in antigen recognition and T cell activation and has been shown to play a role in thymic differentiation. Two domains in CD8a are important for function: the extracellular IgSF domain binds the α3 domain of MHC class I and the cytoplasmic CXCP motif binds the tyrosine kinase p56 Lck.Product Details
- Verified Reactivity
- Antibody Type
- Host Species
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
- The antibody was purified by affinity chromatography and conjugated with Spark YG™ 593 under optimal conditions.
- Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
* Spark YG™ 593 has a maximum excitation of 573 nm and a maximum emission of 593 nm.
- Excitation Laser
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
AB_2904332 (BioLegend Cat. No. 303807)
AB_2904332 (BioLegend Cat. No. 303808)
- reIg superfamily, homodimer or heterodimer with CD8b, 32-34 kD
Majority of thymocytes, T cell subset, NK cells
- MHC Class I molecules
- Cell Type
- NK cells, T cells, Thymocytes
- Biology Area
- Molecular Family
- CD Molecules
- Antigen References
1. Barclay N, et al. 1993. The Leucocyte Antigen FactsBook. Academic Press Inc. San Diego.
- Gene ID
- 925 View all products for this Gene ID
- View information about CD8 on UniProt.org
Related Pages & Pathways
Other FormatsView All CD8 Reagents Request Custom Conjugation
|PE anti-human CD8 Recombinant Antibody||QA18A37||FC|
|Spark Violet™ 538 anti-human CD8 Recombinant Antibody||QA18A37||FC|
|Purified anti-human CD8 Recombinant Antibody||QA18A37||FC|
|Spark YG™ 593 anti-human CD8 Recombinant Antibody||QA18A37||FC|
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