- A18140A (See other available formats)
- Regulatory Status
- Other Names
- (E3-independent) E2 ubiquitin-conjugating enzyme, E2/E3 hybrid ubiquitin-protein ligase UBE2O, Ubiquitin carrier protein O, Ubiquitin-conjugating enzyme E2 O, Ubiquitin-conjugating enzyme E2 of 230 kD, Ubiquitin-protein ligase O
- Mouse IgG2b, κ
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- Product Citations
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Ubiquitin-conjugating enzyme E2 O (UBE2O) is an E2/E3 hybrid enzyme that displays both E2 and E3 ligases activities and mediates ubiquitination of many target proteins involved in a wide range of processes, including the 5’-AMP-activated protein kinase catalytic subunit a2 (AMPKa2), tumor suppressor ubiquitin carboxyl-terminal hydrolase BAP1, mixed-lineage leukemia (MLL) protein, SMAD family member 6 (SMAD6), transcription factor c-Maf, and free ribosomal proteins. Abnormal expression and mutations in UBE2O are observed in tumorigenesis and are associated with poor prognosis of gastric, lung, breast, and prostate cancers.Product Details
- Human, Mouse, Rat
- Antibody Type
- Host Species
- Recombinant human UBE2O protein
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- The antibody was purified by affinity chromatography.
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
WB - Quality tested
ICC - Verified
- Recommended Usage
Each lot of this antibody is quality control tested by western blotting. For western blotting, the suggested use of this reagent is 0.2 - 5.0 µg/mL. For immunocytochemistry, a concentration range of 0.5 - 10 μg/mL is recommended. It is recommended that the reagent be titrated for optimal performance for each application.
AB_2820188 (BioLegend Cat. No. 870201)
AB_2820189 (BioLegend Cat. No. 870202)
- Human UBE2O is a 1,292 amino acid protein with a predicted molecular mass of 141 kD and observed molecular mass of ~200 kD
Tissue distribution: Brain, skeletal muscle, heart
Cellular distribution: Nucleus, cytosol
- UBE2O is an E2/E3 hybrid ubiquitin-protein ligase that is crucial for protein ubiquitination and degradation.
- Cell Type
- Astrocytes, Microglia, Neurons, Oligodendrocytes
- Biology Area
- Neurodegeneration, Neuroscience, Protein Misfolding and Aggregation, Ubiquitin/Protein Degradation
- Molecular Family
- Antigen References
- Ullah K, et al. 2019. FEBS J. 286(11):2018-2034.
- Chen S, et al. 2018. J Biol Chem. 293(29):11296-11309.
- Mashtalir N, et al. 2014. Mol Cell. 54(3):392-406.
- Gene ID
- 63893 View all products for this Gene ID
- View information about UBE2O on UniProt.org
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