Purified anti-TIMP-1 Antibody

Pricing & Availability
Clone
M2004D03 (See other available formats)
Other Names
Erythroid-potentiating activity (EPA), Fibroblast collagenase inhibitor, Tissue inhibitor of metalloproteinases 1 (TIMP1)
Isotype
Mouse IgG2b
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Product Citations
publications
M2004D03_Purified_TIMP-1_Antibody_WB_033115
Western blot analysis of 50ng recombinant human TIMP-1 (lane 1, Cat. No. 592402), and recombinant mouse TIMP-1 (lane 2, Cat. No. 593702) using anti-TIMP-1 antibody (clone M2004D03) and HRP anti-mouse IgG antibody (Cat. No. 405306).
  • M2004D03_Purified_TIMP-1_Antibody_WB_033115
    Western blot analysis of 50ng recombinant human TIMP-1 (lane 1, Cat. No. 592402), and recombinant mouse TIMP-1 (lane 2, Cat. No. 593702) using anti-TIMP-1 antibody (clone M2004D03) and HRP anti-mouse IgG antibody (Cat. No. 405306).
Cat # Size Price Quantity Avail. Save
676002 100 µg 156€
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Description

TIMP-1 (Tissue inhibitor of metalloproteinase 1) is a glycoprotein that is well recognized for its role in extracellular matrix remodeling through controlling the activity of matrix metalloproteinases (MMPs). Independent of MMP inhibition, TIMPs also act as signaling molecules and plays important roles in cell growth, apoptosis, differentiation, angiogenesis, and oncogenesis. High level of TIMP-1 protein has been found in several types of cancers and associated with a poor patient prognosis. TIMP-1 may be useful as a cancer prognostic marker in combination with urokinase plasminogen activator (uPA) and plasminogen activator inhibitor type-1 (PAI-1).

Product Details
Technical Data Sheet (pdf)

Product Details

Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Recombinant human TIMP-1.
Formulation
This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
Affinity purified.
Concentration
0.5 mg/ml
Storage & Handling
Upon receipt, store undiluted between 2°C and 8°C.
Application

WB - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.25 - 2.0 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.

RRID
AB_2565609 (BioLegend Cat. No. 676002)

Antigen Details

Structure
Belongs to the protease inhibitor I35 (TIMP) family. Contains 1 NTR domain, predicted molecular weight 23 kD.
Distribution
Widely expressed in mammalian tissues, notably in reproductive organs.
Function
TIMP-1 forms complexes with matrix metalloproteinases (MMPs) and inhibits the proteolytic activity of these enzymes.
Interaction
MMP-1, MMP-3, MMP-9.
Ligand/Receptor
CD63.
Biology Area
Angiogenesis, Apoptosis/Tumor Suppressors/Cell Death, Cell Adhesion, Cell Biology
Molecular Family
Enzymes and Regulators
Antigen References

1. Brew K and Nagase H. 2010. Biochim. Biophys. Acta. 1803:55.
2. Murphy G. 2011. Genome Biol. 12:233.
3. Bourboulia D and Stetler-Stevenson WG. 2010. Semin. Cancer Biol. 20:161.
4. Kim YS, et al. 2012. BMB Rep. 45:623.
5. Ries C. 2014. Cell Mol. Life Sci. 71:659.

Gene ID
30949 View all products for this Gene ID
UniProt
View information about TIMP-1 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 1    Revision Date: 09.02.2015

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