Purified anti-RIG-1 Antibody

Pricing & Availability
Clone
SS1A (See other available formats)
Other Names
Retinoic acid-inducible gene 1 protein, DEAD-box protein 58, DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
Isotype
Rat IgG2a, κ
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Product Citations
publications
SS1A_RIG1_Purified_Antibody_WB_012114.jpg
Western blot analysis of extracts from Raw 264.7 cells starved for 20h (lane 1) and starved for 20h and treated with 1 µg/ml LPS for 9h (lane 2) using anti-RIG-1 antibody (clone SS1A).
  • SS1A_RIG1_Purified_Antibody_WB_012114.jpg
    Western blot analysis of extracts from Raw 264.7 cells starved for 20h (lane 1) and starved for 20h and treated with 1 µg/ml LPS for 9h (lane 2) using anti-RIG-1 antibody (clone SS1A).
Cat # Size Price Quantity Avail. Save
635201 25 µg 76€
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Description

RIG-1/DDX58(Retinoic acid-inducible gene 1 protein/ DEAD-box protein 58) is an RNA helicase that belongs to the DEAD/H box. Contains 2 CARD domains, a helicase ATP-binding domain and a helicase C-terminal domain. Predicted molecular weight approximately 107 kD. RIG-1 has an essential function in double-stranded RNA-induced innate antiviral responses. RIG-1 and MDA5 (melanoma differentiation-associated gene 5) are key intracellular receptors that sense intracellular viral infection and trigger a signal forinnate antiviral responses including the production of typeI IFN. Clone SS1A has been shown to be useful for western blotting of the mouse RIG-1 protein.

Product Details
Technical Data Sheet (pdf)

Product Details

Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
Peptide-KLH, C-terminal end of murine RIG-1
Formulation
This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide at 0.5 mg/ml.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
Upon receipt, store undiluted between 2°C and 8°C.
Application

WB - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 1 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.

Product Citations
  1. Wang W, et al. 2016. Proc Natl Acad Sci U S A. 113: 9581 - 9586. PubMed
RRID
AB_940599 (BioLegend Cat. No. 635201)

Antigen Details

Structure
RIG-1 is an RNA helicase that belongs to the DEAD/H box. Contains 2 CARD domains, a helicase ATP-binding domain and a helicase C-terminal domain. Predicted molecular weight approximately 107 kD.
Distribution

Cytoplasm.

Function
Involved in innate immune defense against viruses. RIG-1 has an essential function in double-stranded RNA-induced innate antiviral responses. RIG-1 is one of the key intracellular receptors that sense intracellular viral infection and trigger a signal for
Interaction
Cardif
Biology Area
Cell Biology, Transcription Factors
Antigen References

1. Imaizumi T, et al. 2002. Biochem. Biophys. Res. Commun. 292:274
2. Kato H, et al. 2006. Nature 441:101
3. Kato H, et al. 2005. Immunity 23:19

Gene ID
109906 View all products for this Gene ID
UniProt
View information about RIG-1 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 2    Revision Date: 01.21.2014

For research use only. Not for diagnostic use. Not for resale. BioLegend will not be held responsible for patent infringement or other violations that may occur with the use of our products.

 

*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, www.biolegend.com/ordering#license). BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products, reverse engineer functionally similar materials, or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.

 

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