- MEL62 (See other available formats)
- Regulatory Status
- Other Names
- CSPG4, Chondroitin Sulfate Proteoglycan 4
- Mouse IgG1, κ
- Ave. Rating
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- Product Citations
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CSPG4, best known as neuron-glial antigen 2 (NG2), is a chondroitin sulfate proteoglycan that is frequently used as a marker for oligodendrocyte progenitor cells. NG2 plays an important role in cell proliferation and migration. It also stabilizes cell-substratum interactions during early events in melanoma cell invasion on the endothelial basement membranes. Missense mutations in NG2 are segregated in familial forms of schizophrenia, implicating its role in neurodevelopmental disorders.Product Details
- Antibody Type
- Host Species
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
WB - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 5 - 10 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.
- Product Citations
AB_2814616 (BioLegend Cat. No. 867701)
AB_2814617 (BioLegend Cat. No. 867702)
- CSPG4 is a 2322 amino acid protein with predicted molecular mass of ~ 250 kD and observed molecular mass of ~ 260-280 kD.
Tissue Distribution: Ubiquitously expressed
Cellular Distribution: Extracellular, plasma membrane, lysosome, and Golgi apparatus
- NG2 is involved in cell proliferation and migration, and plays an important role in stabilizing cell-substratum interactions.
- MPDZ, PRKCA, TNC, Laminin-1, COL5A1, COL6A2
- Cell Type
- Biology Area
- Cancer Biomarkers, Cell Motility/Cytoskeleton/Structure, Cell Proliferation and Viability, Cell Structure, Neurodegeneration, Neuroinflammation, Neuroscience, Neuroscience Cell Markers
- Antigen References
- Schäfer MKE and Tegeder I. 2018. Matrix Biol. 68-69:571.
- Birey F, et al. 2017. Curr Opin Neurobiol. 47:93.
- Song FE, et al. 2017. CNS Neurosci Ther. 23(7):547.
- Gene ID
- 1464 View all products for this Gene ID
- View information about NG2 on UniProt.org
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