- W16121C (See other available formats)
- Regulatory Status
- Other Names
- IL3BP1, E4 binding protein 4 (E4BP4), NF-IL3A, NFIL3A
- Rat IgG2a, κ
- Ave. Rating
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- Product Citations
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NFIL3, also known as E4BP4, belongs to the basic leucine zipper (bZIP) family of transcription factors. NFIL3 has been shown to bind to the promoter region of the IL-3 gene; IL-3 treatment induces the expression of NFIL3. NFIL3 regulates several immunological processes including Th2 and Th17 cytokine production, Th17 cell differentiation, conventional natural killer (NK) cell differentiation, development of non-NK ILC lineages, and the response of macrophages and dendritic cells. NFIL3 has been found to prevent apoptosis of pro-B lymphocytes and is involved in IgE class switching. NFIL3-deficient mice showed impaired development of NK cells and reduced expression of transcription factors ID2, EOMES, GATA3, and TBX21.Product Details
- Antibody Type
- Host Species
- Human NFIL3 recombinant protein (1-250 a.a.) expressed in E. coli.
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
WB - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 2 µg/mL (1:250-1:1000 diluted). It is recommended that the reagent be titrated for optimal performance for each application.
AB_2687291 (BioLegend Cat. No. 698101)
AB_2687267 (BioLegend Cat. No. 698102)
- 462 amino acids with a predicted molecular weight of 50.9 kD. Contains a basic-leucine zipper (bZIP) domain responsible for DNA binding.
- NFIL3 is a transcription factor that regulates a variety of cellular processes in lymphocyte subsets including cytokine production, class switching, and cell differentiation.
- NFIL3 forms a homodimer and interacts with DR1, PER2, and CRY2.
- Antigen References
1. Xu W, et al. 2015. Cell Rep. 10:2043.
2. Zhu C, et al. 2015. Nat. Commun. 6:6072.
3. Seillet C, et al. 2014. J. Immunol. 192:2667.
4. Keniry M, et al. 2013. Genes Dev. 27:916.
5. Kashiwada M, et al. 2011. EMBO J. 30:2071.
6. Kobayashi T, et al. 2011. J. Immunol. 186:4649.
- Gene ID
- 4783 View all products for this Gene ID
- View information about NFIL3 on UniProt.org
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