- SA367H8 (See other available formats)
- Regulatory Status
- Other Names
- Fas, ALPS1A, APO-1, APT1
- Mouse IgG1, κ
- Ave. Rating
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- Product Citations
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CD95, also known as Fas, is an approximately 45 kD type I transmembrane protein belonging to the TNFR superfamily (TNFRSF6). The expression of CD95 has been described in various organs, such as thymus, spleen, liver, heart, lung and ovary. Upon ligand (FasL) binding, CD95 forms the death-inducing signaling complex (DISC) intracellularly and induce apoptosis of the cell. CD95-induced apoptosis plays important roles in development, as well as in maintining peripheral tolerance of the immune system.Product Details
- Antibody Type
- Host Species
- Mouse Fas Transfectants
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Product Citations
AB_2629777 (BioLegend Cat. No. 152602)
- CD95 (Fas) is an approximately 45 kD type I transmembrane protein; cystiene-rich domain, death domain.
Thymus, spleen, liver, heart, lung, and ovary.
- Induction of apoptosis.
- Caspase 8, caspase 10, CFLAR, FADD, PDCD6, SUMO1, and TNFRSF6.
- Biology Area
- Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Immunology
- Molecular Family
- CD Molecules
- Antigen References
- Ogasawara J, et al. 1995. J Exp Med. 181:485-91.
- Ogasawara J, et al. 1993. Nature. 364:806-9.
- Nishimura Y, et al. 1995. J Immunol. 154:4395-403.
- Gene ID
- 14102 View all products for this Gene ID
- View information about CD95 on UniProt.org
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