- QA17A05 (See other available formats)
- Other Names
- CD3ε, T3, CD3
- Mouse IgG1, κ
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- Product Citations
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CD3ε is a 20 kD transmembrane protein, also known as CD3 or T3. It is a member of the Ig superfamily and primarily expressed on T cells, NK-T cells, and at different levels on thymocytes during T cell differentiation. CD3ε forms a TCR complex by associating with the CD3δ, γ and ζ chains, as well as the TCR α/β or γ/δ chains. CD3 plays a critical role in TCR signal transduction, T cell activation, and antigen recognition by binding the peptide/MHC antigen complex.Product Details
- Antibody Type
- Host Species
- H-2Kb-specific mouse cytotoxic T lymphocyte clone BM10-37
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.06 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
QA17A05 blocks clone 145-2C11, QA17A05 activates T cell proliferation similar to the clone 145-2C11.
AB_2734241 (BioLegend Cat. No. 155702)
- Ig superfamily, forms CD3/TCR complex with CD3δ, γ and ζ subunits and TCR (α/β and γ/δ), 20 kD
Thymocytes (differentiation dependent), mature T cells, NK-T cells
- TCR signal transduction, T cell activation, antigen recognition
- Peptide antigen/MHC-complex
- Cell Type
- NKT cells, T cells, Thymocytes
- Biology Area
- Molecular Family
- CD Molecules, TCRs
- Antigen References
- Barclay AN, Brown MH. 1997. Biochem. Soc. Trans. 25:224-8.
- Davis MM. 1990. Annu. Rev. Biochem. 59:475.
- Weiss A, Littman DR. 1994. Cell. 76:263.
- Gene ID
- 12501 View all products for this Gene ID
- View information about CD3ε on UniProt.org
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