- W19132B (See other available formats)
- Regulatory Status
- Other Names
- SignalingLymphocyte Activation Molecule (SLAM), IPO-3
- Rat IgG2a, λ
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- Product Citations
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CD150 is a 75-95 kD member of the immunoglobulin superfamily, also known as SLAM (signaling lymphocyte activation molecule) or IPO-3. CD150, a single chain type I transmembrane molecule, is expressed on thymocytes, T cell subsets, B cells, dendritic cells, and endothelial cells. The expression is upregulated upon activation. CD150 expression has been shown to be maintained on Th1 but not Th2 clones. T regulatory cells express a relatively high level of CD150. Antibodies against CD150 have been shown to augment IFN-γ production by Th1 cells, especially when co-stimulated through the TCR. CD150 associates with the src homology 2-domain-containing protein tyrosine phosphatase SHP-2, and this association is thought to be involved in signal transduction. In combination with CD48, CD150 is a useful marker for hematopoietic stem cell studies.Product Details
- Antibody Type
- Host Species
- RBL1 transfectant (1-287a.a)
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- The antibody was purified by affinity chromatography.
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Ig superfamily, 75-95 kD
Thymocytes, T cell subset, B lymphocytes, dendritic cells, endothelial cells
- B cell and dendritic cell costimulation
- Antigen References
1. Punnonen J, et al. 1997. J. Exp. Med. 185:993.
2. Gordiienko I, et al. 2019. Clin Immunol. 204:14-22
3. Kiel M, et al. 2005. Cell. 121(7):1109-21
- Gene ID
- 27218 View all products for this Gene ID
- View information about CD150 on UniProt.org
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