- DIH37 (See other available formats)
- Regulatory Status
- Other Names
- IL-5Rα, IL-5 Receptor α subunity
- Rat IgG2a, κ
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- Product Citations
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CD125 is a 60KDa type I transmembrane protein. It is the ligand-specific α subunit of the heterodimeric interleukin 5 (IL-5) receptor. The signal-transducing β subunit of this receptor does not bind to any cytokines and is shared by the receptors for IL-3 and CSF2/GM-CSF. IL-5 is mainly produced by Th2 cells and elevated IL-5 levels are associated with allergic disorders. CD125 has also been found to interact with syndecan binding protein (SDCBP or syntenin), leading to the activation of the transcription factor SOX4. The mouse CD125 is expressed on eosinophils, basophils, and B cells.Product Details
- Antibody Type
- Host Species
- Murine IL-5Ralpha-hFcgamma1 fusion protein
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
AB_2715827 (BioLegend Cat. No. 153402)
- 60 kD type I transmembrane protein
Eosinophils, basophils and B cells
- IL-5 receptor
- JAK2, CD131 (IL3RB, CSF2RB), SDCBP
- Cell Type
- B cells, Basophils, Eosinophils
- Biology Area
- Cell Biology, Cell Proliferation and Viability, Immunology
- Molecular Family
- CD Molecules, Cytokine/Chemokine Receptors
- Antigen References
1. Takaki S, et al. 1990. EMBO J. 9:4367
2. Takatsu K, et al. 2011. Proc. Jpn. Acad. Ser B. 87:463.
3. Hitoshi Y, et al. 1990. J. Immunol. 144:4218.
- Gene ID
- 16192 View all products for this Gene ID
- View information about CD125 on UniProt.org
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