- S18020A (See other available formats)
- Regulatory Status
- Other Names
- SCO1, SOW3, CD117, Tr-kitm, Gsfsco5, c-kit
- Rat IgG1, κ
- Ave. Rating
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- Product Citations
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CD117 is a 145 kD immunoglobulin superfamily member also known as c-kit and stem cell factor receptor (SCFR). It is a transmembrane tyrosine-kinase receptor that binds the c-kit ligand (also known as steel factor, stem cell factor, and mast cell growth factor). CD117 is expressed on hematopoietic stem cells (including multipotent hematopoietic stem cells, progenitors committed to myeloid and/or erythroid lineages, and T and B cell precursors), mast cells, and acute myeloid leukemia (AML) cells. CD117 interaction with its ligand is critical for the development of hematopoietic stem cells.Product Details
- Antibody Type
- Host Species
- Mouse c-kit transfectants
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- The antibody was purified by affinity chromatography.
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.125 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
S18020A has been tested to block the ligand binding of SCF on c-Kit which is determined by the phosphorylation of ERK1/2 in c-Kit signaling.
- Product Citations
AB_2888858 (BioLegend Cat. No. 161502)
- A 145 kD immunoglobulin superfamily member
Hematopoietic stem cells, mast cells, and some acute myeloid leukemia cells
- The development of hepatopoietic stem cells
- Steel factor, stem cell factor, and mast cell growth factor
- Cell Type
- Hematopoietic stem and progenitors, Mast cells
- Antigen References
1. Barclay A, et al. 1997. The Leukocyte Antigen FactsBook (2nd ed.). Academic Press.
2. Galli SJ, et al. 1994. Adv. Immunol. 55:1.
3. Ikuta K, et al. 1992. Annu. Rev. Immunol. 10:759.
4. Besmer P, et al. 1986. Nature 320:415.
5. Witte ON. 1990. Cell 63:5.
- Gene ID
- 16590 View all products for this Gene ID
- View information about CD117 on UniProt.org
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