Purified anti-human KLRG1 (MAFA) Antibody

Pricing & Availability
Clone
14C2A07 (See other available formats)
Regulatory Status
RUO
Other Names
CLEC15A, MAFA-L, MAFA-2F1, MAFA-LIKE, 2F1
Isotype
Mouse IgG2a, κ
Ave. Rating
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Product Citations
publications
14C2A07_PURE_KLRG1_FC_1_093015
Human peripheral blood lymphocytes were stained with purified KLRG1 (clone 14C2A07, top) or purified mouse IgG2a, κ isotype control (bottom) followed by anti-mouse IgG PE. The cells were then stained with CD56 Brilliant Violet 510™.
  • 14C2A07_PURE_KLRG1_FC_1_093015
    Human peripheral blood lymphocytes were stained with purified KLRG1 (clone 14C2A07, top) or purified mouse IgG2a, κ isotype control (bottom) followed by anti-mouse IgG PE. The cells were then stained with CD56 Brilliant Violet 510™.
  • 14C2A07_PURE_KLRG1_FC_2_093015
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368602 100 µg 148,00€
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Description

Killer cell lectin-like receptor subfamily G member (KLRG1) is a 30 kD, type II membrane glycoprotein with one C-type lectin domain and one immunoreceptor tyrosine-based inhibitory motif (ITIM). KLRG1 is expressed by subsets of natural killer cells (NKs) and effector and memory T cells. It inhibits cell activation and proliferation and is also a marker of T cell senescence. The binding of KLRG1 to E-, N-, or R- cadherins blocks phosphorylation of AKT and increases the expression of cell cycle inhibitors.

Product Details
Technical Data Sheet (pdf)

Product Details

Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Human KLRG1-transfected cells.
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Product Citations
  1. Friebel E, et al. 2020. Cell. 181(7):1626-1642.e20. PubMed
RRID
AB_2566256 (BioLegend Cat. No. 368602)

Antigen Details

Structure
Type II membrane glycoprotein, one C-type lectin domain, one ITIM, 30 kD.
Distribution

Subsets of natural killer cells, effector and memory T cells.

Function
Inhibits cell activation and proliferation
Interaction
AKT.
Ligand/Receptor
E-, N-, R- cadherins.
Cell Type
NK cells, T cells
Biology Area
Immunology
Antigen References

1. Shi L, et al. 2014. J. Immunol. 192:649.

Gene ID
10219 View all products for this Gene ID
UniProt
View information about KLRG1 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 1    Revision Date: 11.23.2015

For research use only. Not for diagnostic use. Not for resale. BioLegend will not be held responsible for patent infringement or other violations that may occur with the use of our products.

 

*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, www.biolegend.com/ordering#license). BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products, reverse engineer functionally similar materials, or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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