- 10D1-J16 (See other available formats)
- Regulatory Status
- Other Names
- Chemokine (C-X-C motif) receptor 7, RDC1, CMKOR1, GPR159, ACKR3
- Mouse IgG2a, κ
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- Product Citations
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CXCR7, also known as RDC1, belongs to a subgroup of C-X-C chemokine receptors, which are part of a large protein family of G protein-coupled receptors (GPCR). CXCR7 binds with a high-affinity to CXCL12/SDF-1 and CXCL11/I-TAC, which regulates the trafficking and activation of leukocytes. It is also a co-receptor for the entry of HIV-1. The binding of a ligand to CXCR7 induces proliferation and migration of immature neurons, glia, and their precursors. CXCR7 expression occurs on a wide variety of tissues and cells including monocytes, B cells, T cells, and mature dendritic cells. Surface expression of CXCR7 has been also reported in tumor cells, activated endothelial cells, and fetal liver cells.Product Details
- Antibody Type
- Host Species
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤2.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
AB_2565219 (BioLegend Cat. No. 391402)
- G Protein-Coupled Receptor super family
- Monocytes, B cells, T cells, and mature dendritic cells.
- Regulates trafficking and activation of leukocytes.
- CXCL12/SDF-1 and CXCL11/I-TAC.
- Cell Type
- Monocytes, B cells, T cells, Dendritic cells
- Biology Area
- Cell Biology, Immunology, Signal Transduction
- Molecular Family
- CD Molecules, Cytokine/Chemokine Receptors, GPCR
- Antigen References
1. Torossian F, et al. 2014. Blood 123:191.
2. Walentowicz-Sadlecka M, et al. 2014. PLoS One 1:e84629.
3. Yates TJ, et al. 2013. Cancer 119:61.
4. Burns JM, et al. 2006. J. Exp. Med. 203:2201.
5. Infantino S, et al. 2006. J. Immunol. 176:2197.
- Gene ID
- 57007 View all products for this Gene ID
- View information about CXCR7 on UniProt.org
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