- NKI-M9 (See other available formats)
- Regulatory Status
- IV 103
- Other Names
- Vitronectin receptor α chain, Integrin αV, αV integrin, ITGAV
- Mouse IgG2a, κ
- Ave. Rating
- Submit a Review
- Product Citations
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CD51 is a type I integral membrane glycoprotein, known as vitronectin receptor α chain, or integrin αV. It forms heterodimer with integrin β1 (CD29), β3 (CD61), β5, β6, or β8. CD51 contains two disulfide-linked subunits of 125 kD and 24 kD, and is expressed on endothelial cells, fibroblasts, macrophages, platelets, osteoclasts, neuroblastoma, melanoma, and hepatoma cells. Many extracellular matrix proteins with RGD-motifs are CD51 ligands. In association with its β chains, CD51 binds vitronectin, von Willebrand factor, fibronectin, thrombospondin, osteopontin, fibrinogen, and laminin. CD51, as an adhesion molecule, plays important roles in leukocytes homing and rolling, mediates bone absorption and angiogenesis.Product Details
- Antibody Type
- Host Species
- Melonama cells
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
FC - Quality tested
ICC - Verified
ELISA, Block, IP - Reported in the literature, not verified in house
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 2.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
(PubMed link indicates BioLegend citation)
- Knapp W, et al. Eds. 1989. Leucocyte Typing IV. Oxford University Press. New York.
- Defilippi P, et al. 1991. J. Cell Biol. 114:855. PubMed
- Burdick MM, et al. 2003. Am. J. Physiol.Cell Ph. 284:C977. PubMed
- Grzeszkiewicz TM, et al. 2001. J. Biol. Chem. 276:21943.
- Sonnenberg A, et al. 1990. J. Cell Biol. 110:2145. PubMed
- Silverman AP, et al. 2008. J Mol Biol. 385:1064. PubMed
- Khurana S, et al. 2013. Blood. 121:2587. PubMed
- Product Citations
AB_2129615 (BioLegend Cat. No. 327902)
- Integrin, forms heterodimer with integrin β1 (CD29), β3 (CD61), β5, β6, or β8, 125 kD and 24 kD in reduced condition, 150 kD (unreduced)
Endothelial cells, fibroblasts, macrophages, platelets, osteoclasts, neuroblastoma, melanoma, and hepatoma cells.
- Adhesion, angiogenesis
- Vitronectin, von Willebrand factor, fibrinogen, thrombospondin, osteopontin, denatured collagen, fibronectin, laminin.
- Cell Type
- Endothelial cells, Fibroblasts, Macrophages, Mesenchymal Stem Cells, Osteoclasts, Platelets
- Biology Area
- Angiogenesis, Cell Adhesion, Cell Biology, Costimulatory Molecules, Immunology, Stem Cells
- Molecular Family
- CD Molecules
- Antigen References
1. Nesbitt S, et al. 1993. J. Biol. Chem. 268:16737.
2. Zola H, et al. 2007. Leukocyte and Stromal Cell Molecules:The CD Markers Wiley-Liss A John Wiley & Sons Inc, Publication
- Gene ID
- 3685 View all products for this Gene ID
- View information about CD51 on UniProt.org
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