Purified anti-human CD370 (CLEC9A/DNGR1) Antibody

Pricing & Availability
8F9 (See other available formats)
Regulatory Status
HCDM listed
Other Names
C-type lectin family member 9A, CD370
Mouse IgG2a, κ
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Product Citations
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353802 100 µg 140,00€
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CD370 (CLEC9A), also known as DNGR1, is a type II transmembrane protein consisting of a single extracellular C-type lectin domain (CTLD) that is connected to the transmembrane domain by a stalk region, and an intracellular cytoplasmic tail with immunoreceptor tyrosine-based activation motif (ITAM). In humans, CLEC9A is strictly expressed on BDCA3-positive conventional dendritic cells (cDC) and CD16- monocytes. CLEC9A recognizes a ubiquitous preformed acid-labile protein associated ligand(s) that is exposed on necrotic cells. CLEC9A ligation is necessary for efficient cross-presentation of dead-cell-associated antigen by recruitment and activation of the tyrosine kinase Syk.

Product Details
Technical Data Sheet (pdf)

Product Details

Antibody Type
Host Species
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
The antibody was purified by affinity chromatography.
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Product Citations
  1. Alcántara‐Hernández M et al. 2017. Immunity. 47(6):1037-1050 . PubMed
  2. Jordan S, et al. 2020. Cell. 178(5):1102-1114.e17.. PubMed
  3. Cytlak U, et al. 2020. Immunity. 53(2):353-370. PubMed
  4. Leylek R, et al. 2020. Cell Rep. 32:108180. PubMed
AB_10983070 (BioLegend Cat. No. 353802)

Antigen Details

Type II transmembrane glycoprotein; consists of a 35 amino acid (aa) cytoplasmic domain with an ITAM like motif, a 21 aa transmembrane segment, a 185 aa extracellular domain (ECD) that contains a stalk region, and one C-type lectin domain (CTLD).

Dendritic subsets including plasmacytoid dendritic cells.

Cross-present antigen to CTL, phagocytosis necrotic cells.
Necrotic cells.
Ubiquitous preformed acid-labile protein associated ligand(s).
Cell Type
Dendritic cells
Biology Area
Immunology, Innate Immunity
Molecular Family
CD Molecules, MHC Antigens
Antigen References

1. Poulin LF, et al. 2010. J. Exp. Med. 207:1261.
2. Sancho D, et al. 2009. Nature 458:899.
3. Huysamen C, et al. 2008. J. Biol. Chem. 283:16693.

Gene ID
283420 View all products for this Gene ID
View information about CD370 on UniProt.org

Related FAQs

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Go To Top Version: 3    Revision Date: 01.22.2015

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Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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