- 14H4 (See other available formats)
- Regulatory Status
- Other Names
- Neuropilin 1
- Mouse IgG2b, κ
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- Product Citations
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The membrane isoform of CD304 is a receptor that regulates angiogenesis and organogenesis in response to growth factors of the VEGF family. CD304 forms a complex with VEGFR2/KDR, resulting in increased cell migration and chemotaxis. In the nervous system, CD304 complexed with plexin mediates Sema-3A signaling and may be involved in axon guidance.Product Details
- Antibody Type
- Host Species
- 293E expressed human CD304 recombinant protein, b isoform
- This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.05% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- Upon receipt, store undiluted between 2°C and 8°C.
WB - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. Western blotting, suggested working dilution(s): Use 10 µl per 5 ml antibody dilution buffer for each mini-gel (1 µg/ml). It is recommended that the reagent be titrated for optimal performance for each application.
AB_11203898 (BioLegend Cat. No. 652301)
AB_11203372 (BioLegend Cat. No. 652302)
- Single-pass type I membrane protein, 103 kD. Contains two CUB motifs, domains similar to coagulation factors V and VIII, and a MAM domain in the extracellular domain. Isoform b is a soluble form.
Membrane, Secreted (isoform b).
- CD304 is a VEGF co-receptor involved in axon guidance, angiogenesis. and development of cardiovascular system. The secreted isoform inhibits binding of VEGF-165 to cells.
- CD304 is a receptor for members of VEGF family and pro-angiogenesis cytokines, such as VEGF-A165, VEGF-B, VEGF-E, and PIGF-2.
- Biology Area
- Angiogenesis, Cell Biology, Immunology, Signal Transduction
- Molecular Family
- CD Molecules
- Antigen References
1. Soker S, et al. 1998. Cell 92:735.
2. Shintani Y, et al. 2006. EMBO J. 25:3045.
3. He Z, et al. 1997. Cell 90:739.
4. Gagnon ML, et al. 2000. P. Natl. Acad. Sci. USA 97:2573.
5. Glinka Y, et al. 2011. Carcinogenesis 32:613.
- Gene ID
- 8829 View all products for this Gene ID
- View information about CD304 on UniProt.org
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