Purified anti-human CD275 (B7-H2, ICOSL) Antibody

Pricing & Availability
2D3 (See other available formats)
Other Names
CD275, ICOSL, B7H2, ICOS-L, B7RP-1, B7-RP1
Mouse IgG2b, κ
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Product Citations
Human monocyte-derived dendritic cells stained with purified 2D3, then detected with biotinylated anti-mouse IgGs and Sav-PE
  • 2D3
    Human monocyte-derived dendritic cells stained with purified 2D3, then detected with biotinylated anti-mouse IgGs and Sav-PE
Cat # Size Price Quantity Avail. Save
309402 100 µg 76€
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B7-H2, a member of the B7 family and the immunoglobulin superfamily, is a 40 kD protein also known as B7RP-1, B7h, B7-H2, GL50 and ICOS Ligand. Human B7-H2 is expressed by B lymphocytes, activated monocytes/macrophages, and dendritic cells. B7-H2 binds to a CD28-like receptor, inducible costimulator molecule (ICOS, AILIM, CRP-1), which is expressed by activated T cells. The interaction of ICOS with B7-H2 plays an important role in the T cell costimulation pathway.

Product Details
Technical Data Sheet (pdf)

Product Details

Antibody Type
Host Species
Human B7H2-mIg fusion protein
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
The antibody was purified by affinity chromatography.
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.5 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application References

(PubMed link indicates BioLegend citation)
  1. Kurosawa S, et al. 2003. Am. J. Respir. Cell Mol. Biol. 28:563.
Product Citations
  1. Wei SC et al. 2017. Cell. 170(6):1120-1133 . PubMed
AB_314768 (BioLegend Cat. No. 309402)

Antigen Details

Ig superfamily, B7 family, 40 kD

B cells and dendritic cells

Binds ICOS on antigen-activated T cells and mediates proliferation and cytokine production
Cell Type
B cells, Dendritic cells
Biology Area
Costimulatory Molecules, Immunology
Molecular Family
CD Molecules
Antigen References
  1. Wang S, et al. 2002. J. Biol. Chem. 96:2808.
  2. Wong SC, et al. 2003. Blood 102:1831.
Gene ID
23308 View all products for this Gene ID
View information about CD275 on UniProt.org

Related FAQs

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Go To Top Version: 2    Revision Date: 07.08.2013

For research use only. Not for diagnostic use. Not for resale. BioLegend will not be held responsible for patent infringement or other violations that may occur with the use of our products.


*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, www.biolegend.com/ordering#license). BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products, reverse engineer functionally similar materials, or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.


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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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