- 6588-5 (See other available formats)
- Other Names
- GPR-2, C-C chemokine receptor 10
- Armenian Hamster IgG
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- Product Citations
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CCR10, also known as GPR-2, is a G-protein-coupled seven transmembrane CC-chemokine receptor. It is the receptor of CCL27 (CTACK/ALP/ILC/ESkine) and CCL28 (MEC) and is expressed on a small subset of T memory cells, IgA-secreting cells, EBV-immortalized B cells, dermal microvascular endothelial cells and dermal fibroblasts. The interaction of CCR10 with its ligands plays a role in the regulation of T cell homing into cutaneous site and IgA-secreting cells migration.Product Details
- Human, African Green, Baboon, Cynomolgus, Rhesus
- Antibody Type
- Host Species
- Armenian Hamster
- N-terminal peptide of human CCR10
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 106 cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
It has been observed that clone 6588-5 can interact with some tandem-dye antibody conjugates during multi-color staining, potentially leading to unwanted staining. These dyes include PE/Cy7, PE/Cy5, PE/Dazzle™ 594, APC/Cy7, APC/Fire™ 750, and PerCP/Cy5.5. This interaction can be resolved by sequentially staining with the 6588-5 antibody first and then followed by other antibodies of interest.
AB_1595419 (BioLegend Cat. No. 341502)
- G-protein-coupled seven transmembrane protein
Small subsets of T memory cells and IgA-secreting cells, EBV-immortalized B cells, dermal microvascular endothelial cells and dermal fibroblasts
- T cell homing into cutaneous site, regulation of IgA-secreting cells migration
- CCL27 (CTACK/ALP/ILC/ESkine), CCL28 (MEC)
- Cell Type
- T cells, B cells, Endothelial cells, Fibroblasts
- Biology Area
- Molecular Family
- CD Molecules, Cytokine/Chemokine Receptors, GPCR
- Antigen References
1. Hudak S, et al. 2002. J. Immunol. 169:1189
2. Kunkel EJ, et al. 2003. J. Clin. Invest. 111:1001
3. Homey B, et al. 2002. Nature Medicine. 8:157
4. Nakayama T, et al. 2002. J. Virol. 76:3072
- Gene ID
- 2826 View all products for this Gene ID
- View information about CCR10 on UniProt.org
- Does staining at room temperature or even at 37°C help for checking chemokine receptors expression?
Due to continuous recycling of many chemokine receptors, it may be worthwhile to consider staining at room temperature or at 37°C if the staining at lower temperature (which can potentially reduce receptor turnover) is not optimal.
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