- A20069I (See other available formats)
- Other Names
- Angiotensin-converting enzyme 2, ACE-related carboxypeptidase, ACE-2, ACEH
- Rat IgG2a, κ
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Angiotensin-converting enzyme 2 (ACE2) is a type one transmembrane protein, which shares approximately 60% homology with ACE. The predicted human ACE2 protein sequence consists of 805 amino acids, including an N-terminal signal peptide, a single catalytic domain, a C-terminal membrane anchor, and a short cytoplasmic tail. ACE2 catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7 involved in vasoconstriction. Recently, ACE2 has been shown to be a functional receptor for the spike glycoprotein of the human coronavirus HCoV-NL63 and the human severe acute respiratory syndrome coronaviruses, SARS-CoV and SARS-CoV-2 (COVID-19 virus). Based on recent single-cell RNA sequencing (scRNA-Seq) database, high ACE2 RNA expression was identified in type II alveolar cells (AT2) of lung, esophagus upper and stratified epithelial cells, kidney proximal tubule cells, enterocytes in ileum and colon, cholangiocyte in bile duct, myocardial cells in heart, and endothelium and vascular smooth muscle cells.Product Details
- Antibody Type
- Host Species
- Recombinant protein cover extracellular domain of ACE2 (Gln 18-Ser740)
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- The antibody was purified by affinity chromatography.
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
IHC-P - Quality tested
WB - Verified
- Recommended Usage
Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry, a concentration range of 5 - 10 µg/mL is suggested. For western blotting, the suggested use of this reagent is 0.1 - 1.0 µg/mL. It is recommended that the reagent be titrated for optimal performance for each application.
AB_2860958 (BioLegend Cat. No. 375801)
AB_2860959 (BioLegend Cat. No. 375802)
- Type one transmemberance protein. Protein sequence consistent extracellular domain (Gln 18-Ser740 ) contain cytalitic domain, transmembrane domain (AA741-AA761) and cytoplasmic domain (AA762-AA805).
Type II alveolar cells (AT2) of lung, esophagus upper and stratified epithelial cells, kidney proximal tubule cells, enterocytes in ileum and colon, cholangiocyte in bile duct, myocardial cells in heart, endothelium and vascular smooth muscle cells
- Catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7 involved in vasoconstriction
- Angiotensin II, ADAM17, TMPRSS2
- Functional receptor for the spike glycoprotein of the human coronavirus HCoV-NL63 and the human severe acute respiratory syndrome coronaviruses, SARS-CoV and SARS-CoV-2 (COVID-19 virus)
- Cell Type
- Biology Area
- Angiogenesis, COVID-19, Immunology
- Molecular Family
- Enzymes and Regulators
- Antigen References
- South AM, et al. 2020. Nat Rev Nephrol. 16:305-7.
- Hoffmann M, et al. 2020. Cell. 181:271-80.
- Sungnak W, et al. 2020. Nat Med. 26:681-7.
- Li W, et al. 2003. Nature. 426:450-4.
- Heurich A, et al. 2014. J Virol. 88:1293-30.
- Hamming I, et al. 2004. J Pathol. 203:631-7.
- Gene ID
- 59272 View all products for this Gene ID
- View information about ACE2 on UniProt.org
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