- W15133A (See other available formats)
- Other Names
- Extracellular signal-regulated kinase 1, Mitogen-activated protein kinase 3 (MAPK3), p44ERK1, p44-MAPK, PRKM3
- Rat IgG2a, κ
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- Product Citations
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ERK1 is a member of mitogen-activated kinases (MAPKs) of serine/threonine protein kinases. ERK1 and ERK2 share 85% homology and both are involved in the MAP kinase signaling cascade. ERK1/2 can be activated by a range of extracellular stimuli, such as mitogen, growth factors, neurotransmitters, chemokines, and cytokines, through receptor tyrosine kinases (RTK), G protein-coupled receptors (GPCRs), or protein kinase C (PKC). Upon stimulation, ERK1/2 are phosphorylated by the upstream kinase MEK on residues Thr202 and Tyr204 and in turn phosphorylate many other downstream molecules that are involved in a range of cellular processes such as cell proliferation, differentiation, motility and cell death.Product Details
- Human, Mouse
- Antibody Type
- Host Species
- Partial human ERK1 recombinant protein (180-379 a.a.) expressed in E. coli.
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
WB - Quality tested
KO/KD-WB - Verified
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.2 - 1.0 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.
AB_2616892 (BioLegend Cat. No. 687002)
- 379 amino acids with a predicted molecular weight of 43.1 kD. Contains a kinase domain responsible for phosphorylation of down stream substrates.
Nucleus and cytoplasm.
- ERK1 is a serine/threonine kinase which acts as a key component of the MAP kinase signaling pathway. ERK1 and ERK2 have been shown to play redundent roles in cell proliferation, differentiation, migration, survival, and apoptosis.
- Interacts with ADAM15, ARRB2, CANX, DAPK1, HSF4, IER3, MAP2K1/MEK1, MORG1, NISCH, SGK1, TPR, CDKN2AIP, PEA15, and MKNK2.
- Biology Area
- Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Neuroscience, Signal Transduction, Synaptic Biology
- Molecular Family
- Postsynaptic proteins, Protein Kinases/Phosphatase
- Antigen References
1. Futran AS, et al. 2013. Curr. Biol. 23:R972.
2. Mendoza MC, et al. 2011. Trends Biochem. Sci. 36:320.
3. Chambard JC, et al. 2007. Biochim. Biophys. Acta. 1773:1299.
4. Roux PP, et al. 2004. Microbiol. Mol. Biol. Rev. 68:320.
5. Torii S, et al. 2004. J. Biochem. 136:557.
6. Clark EA, et al. 1996. J. Biol. Chem. 271:14814.
- Gene ID
- 5595 View all products for this Gene ID
- View information about ERK1 on UniProt.org
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