- A17050E (See other available formats)
- Regulatory Status
- Other Names
- DRD1, Dopamine Receptor D1
- Mouse IgG2b, κ
- Ave. Rating
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- Product Citations
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The D1 subtype of the dopamine receptor (DRD1) is a Gs/a-protein coupled receptor mainly expressed in the caudate putamen of the central nervous system. Upon binding to its ligand, DRD1 indirectly activates cyclic AMP-dependent protein kinase and regulates neuronal development. Two transcript variants, DRD1a and DRD1b exist in vivo. DRD1 has been discovered to modulate DRD2-mediated signaling pathway. DRD1 and DRD2 also form heterodimers via C-terminal regions, which has been reported to be involved in phospholipase C and CaMKII activation, and BDNF production.Product Details
- Human, Mouse, Rat
- Antibody Type
- Host Species
- Recombinant human DRD1
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
WB - Quality tested
IHC-P - Verified
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 10 µg per ml. For immunohistochemistry on formalin-fixed paraffin-embedded tissue, a concentration range of 5.0 - 10 µg/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
AB_2783448 (BioLegend Cat. No. 856001)
AB_2783449 (BioLegend Cat. No. 856002)
- DRD1 is a 446 amino acid protein with an apparent molecular mass of ~ 49 kD.
Tissue Distribution: Mainly expressed in the midbrain.
Cellular Distribution: Plasma membrane.
- DRD1 is involved in dopamine related signaling and neuronal development.
- Interacts with DRD2, DNAJC14, and DRD1IP.
- Receptor of Dopamine
- Biology Area
- Cell Biology, Neuroscience, Neuroscience Cell Markers, Synaptic Biology
- Molecular Family
- Adhesion Molecules, GPCR
- Antigen References
- Amare AT, et al. 2017. EPMA J. 8(3):211
- Arango-Lievano M, et al. 2015. Med Sci (Paris). 31(5):546
- Serretti A, et al. 2007. J Alzheimers Dis. 12(1):73
- Gene ID
- 1812 View all products for this Gene ID 13488 View all products for this Gene ID
- View information about Dopamine Receptor D1 on UniProt.org
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