Purified anti-CD304 (Neuropilin 1) Antibody

Pricing & Availability
Clone
A18190A (See other available formats)
Regulatory Status
RUO
Other Names
Vascular Endothelial Cell Growth Factor 165 Receptor, Neuropilin-1
Isotype
Mouse IgG2a, κ
Ave. Rating
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Product Citations
publications
A18190A_PURE_CD304_Antibody_050620
Western blot of purified anti-CD304 (Neuropilin 1) antibody (clone A18190A). Lane 1, 5: Molecular weight marker; Lane 2: 40 µg of human brain lysate; Lane 3: 10 µg of MCF7 cell lysate; Lane 4: 10 µg of SH-SY5Y cell lysate. The blot was incubated with 5 µg/mL of the primary antibody overnight at 4°C, followed by incubation with HRP goat anti-mouse IgG antibody (Cat. No. 405306). Enhanced chemiluminescence was used as the detection system. MCF7 and SH-SY5Y cell lysates were loaded in order of decreasing CD304 expression; predicted expression data was obtained from Human Protein Atlas.
  • A18190A_PURE_CD304_Antibody_050620
    Western blot of purified anti-CD304 (Neuropilin 1) antibody (clone A18190A). Lane 1, 5: Molecular weight marker; Lane 2: 40 µg of human brain lysate; Lane 3: 10 µg of MCF7 cell lysate; Lane 4: 10 µg of SH-SY5Y cell lysate. The blot was incubated with 5 µg/mL of the primary antibody overnight at 4°C, followed by incubation with HRP goat anti-mouse IgG antibody (Cat. No. 405306). Enhanced chemiluminescence was used as the detection system. MCF7 and SH-SY5Y cell lysates were loaded in order of decreasing CD304 expression; predicted expression data was obtained from Human Protein Atlas.
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871601 25 µg 72,00€
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871602 100 µg 188,00€
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Description

CD304 (Neuropilin 1) is a membrane receptor that plays a role in establishment of certain neuronal circuits during neurogenesis, as well as in  organogenesis outside of the nervous system. CD304 binds semaphorin 3A and VEGFA. The interaction between CD304 and VEGFA initiates a signaling pathway that is needed for cell migration and axonal guidance in the motor neuron system.

Product Details
Technical Data Sheet (pdf)

Product Details

Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/mL
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

WB - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by western blotting. For western blotting, the suggested use of this reagent is 5.0 - 10 µg/mL. It is recommended that the reagent be titrated for optimal performance for each application.

RRID
AB_2861111 (BioLegend Cat. No. 871601)
AB_2861112 (BioLegend Cat. No. 871602)

Antigen Details

Structure
CD304 is a 923 amino acid protein with predicted molecular mass of ~103 kD and observed molecular mass at ~ 120 kD.
Distribution

Tissue Distribution: Ubiquitously expressed
Cellular Distribution: Plasma membrane, extracellular, cytosol, cytoskeleton, endosome

Function
CD304 is involved in signaling that is needed for cell migration and axonal guidance.
Ligand/Receptor
Semaphorin 3A, VEGFA
Cell Type
Endothelial cells
Biology Area
Angiogenesis, Neurodegeneration, Neuroscience, Neuroscience Cell Markers
Molecular Family
Semaphorin Receptors
Antigen References
  1. Niland S, Eble JA. 2019. Int. J. Mol. Sci. 20(3).
  2. Gudapati P, et al. 2020. Cytometry B. Clin. Cytom. 10.1002/cyto.b.21866.
  3. Ding Z, et al. 2019. Mol. Carcinog. 58:1019.
Gene ID
8829 View all products for this Gene ID
UniProt
View information about CD304 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 1    Revision Date: 05.06.2020

For research use only. Not for diagnostic use. Not for resale. BioLegend will not be held responsible for patent infringement or other violations that may occur with the use of our products.

 

*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, www.biolegend.com/ordering#license). BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products, reverse engineer functionally similar materials, or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.

 

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Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

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