- 1E7-C9-D10-B10 (See other available formats)
- Regulatory Status
- Other Names
- BRCA1 Associated Protein
- Mouse IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
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BRCA1 associated protein (BRAP) is a cytosolic protein that negatively regulates MAP kinase activation by inhibiting the formation of the Raf/MEK complex. BRAP also inhibits nuclear translocation and promotes the retention of several proteins, including BRCA1, in the cytoplasm by binding to their nuclear localization signal sequence.Product Details
- Human, Mouse, Rat
- Antibody Type
- Host Species
- Purified recombinant human BRAP protein fragments expressed in E. coli
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- The antibody was purified by affinity chromatography.
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
WB - Quality tested
IHC-P - Verified
- Recommended Usage
Each lot of this antibody is quality control tested by western blotting. For western blotting, the suggested use of this reagent is 0.5 - 2.0 µg/mL. For immunohistochemistry on formalin-fixed paraffin-embedded tissue sections, a concentration range of 2.0 - 10 µg/mL is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
- Product Citations
AB_2832876 (BioLegend Cat. No. 871001)
AB_2832877 (BioLegend Cat. No. 871002)
- BRAP is an 592 amino acid protein with predicted and observed molecular mass of ~67 kD.
Tissue Distribution: Ubiquitously expressed
Cellular Distribution: Nucleus, Cytosol
- Protein trafficking, Epigenetics
- BRCA1, Galectin-2
- Cell Type
- Astrocytes, Dopaminergic Neurons, GABAergic Neurons, Glutamatergic Neurons, Mature Neurons, Microglia, Neural Stem Cells, Neurons, Oligodendrocytes
- Biology Area
- Cell Biology, Innate Immunity, Neurodegeneration, Neuroinflammation, Neuroscience, Protein Trafficking and Clearance, Ubiquitin/Protein Degradation
- Molecular Family
- Innate Immune Signaling
- Antigen References
- Modell SM, et al. 2014. J Relig Health. 53(3):715.
- Castro E & Eeles R. 2012. Asian J Androl. 14(3):409.
- Pristauz G, et al. 2010. Wien Med Wochenschr. 160(7-8):158.
- Gene ID
- 8315 View all products for this Gene ID 72399 View all products for this Gene ID
- View information about BRAP on UniProt.org
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