- ROS195G (See other available formats)
- Regulatory Status
- Other Names
- B lymphocyte-induced maturation protein-1, PRDM-1, BLIMP1
- Mouse IgG1
- Ave. Rating
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- Product Citations
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Blimp-1 is a 98 Kd protein containing five Kuppel-type zinc finger domains that confer sequence specific DNA binding. It has been postulated to be a master regulator of terminal B cell differentiation. In the BCL-1 lymphoma model of differentiation from mature B cells to plasma cells, ectopic expression of Blimp-1 is sufficient to cause terminal differentiation manifested by loss of surface immunoglobulin, IgM secretion, expression of syndecan-1 and cessation of cell division. Recently, it is reported that Blimp-1 is also involved in T cell differentiation and T cell homeostasis and suppression of IL-2 production.Product Details
- Verified Reactivity
- Reported Reactivity
- Antibody Type
- Host Species
- Recombinant GST-blimp-1 protein
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
WB - Quality tested
IHC, IP, ICC, ELISA - Reported in the literature, not verified in house
- Recommended Usage
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 5 µg per mL. It is recommended that the reagent be titrated for optimal performance for each application.
(PubMed link indicates BioLegend citation)
- Product Citations
AB_2300132 (BioLegend Cat. No. 648202)
- 98 Kd protein containing five Kruppel-type zinc finger domains
Expressed in CD4+ and CD8+ effector/memory T cells and in Foxp3+ T reg cells. In the B cell lineage, it is specifically expressed in the antibody secreting cells.
- A transcription repressor expressed in B and T cells.
- Cell Type
- B cells, T cells, Tregs
- Biology Area
- Molecular Family
- Nuclear Markers
- Antigen References
1. Zhao WL, et al. 2008. Blood 111:3867.
2. Climmino L, et al. 2008. J. Immunol. 181:2338.
3. Martins G and Calame K. 2008. Annu Rev Immunol. 26:133.
- Gene ID
- 639 View all products for this Gene ID
- View information about Blimp-1 on UniProt.org
|Purified anti-Blimp-1||ROS195G||WB, IHC, IP, ICC, ELISA|
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