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Purified anti-β-Amyloid, x-38 Recombinant Antibody

Pricing & Availability
Clone
QA18A68 (See other available formats)
Regulatory Status
RUO
Other Names
AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN-II, PN2, Amyloid beta A4 protein, preA4, protease nexin-II, peptidase nexin-II, beta-amyloid peptide, alzheimer disease amyloid protein, cerebral vascular amyloid peptide, APP, Amyloid Precursor Protein
Isotype
Rabbit IgG
Ave. Rating
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Product Citations
publications
QA18A68_PURE_beta-Amyloid_Recom_Antibody_050922
Human β-Amyloid Peptide (1-38) (red) or Human β-Amyloid Peptide (1-40) (blue) (Cat. No. 932602) coated onto 96-well ELISA plates at 2 µg/mL in ELISA Coating Buffer (Cat. No. 421701) were incubated with a dilution series of purified anti-β-Amyloid, x-38 recombinant antibody (clone QA18A68) in ELISA Assay Diluent B (Cat. No. 421205). Bound antibody was detected with HRP Donkey anti-rabbit IgG (Cat. No. 406401) and TMB substrate set (Cat. No. 421101). Absorbance was measured at 450 nm.
  • QA18A68_PURE_beta-Amyloid_Recom_Antibody_050922
    Human β-Amyloid Peptide (1-38) (red) or Human β-Amyloid Peptide (1-40) (blue) (Cat. No. 932602) coated onto 96-well ELISA plates at 2 µg/mL in ELISA Coating Buffer (Cat. No. 421701) were incubated with a dilution series of purified anti-β-Amyloid, x-38 recombinant antibody (clone QA18A68) in ELISA Assay Diluent B (Cat. No. 421205). Bound antibody was detected with HRP Donkey anti-rabbit IgG (Cat. No. 406401) and TMB substrate set (Cat. No. 421101). Absorbance was measured at 450 nm.
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605452 100 µg 295€
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Description

Amyloid beta (Aβ or Abeta) denotes peptides of 36-43 amino acids in length that are crucially involved in Alzheimer's disease as the main component of the amyloid plaques found in the brains of Alzheimer patients. The peptides result from the amyloid precursor protein (APP), which is cut by certain enzymes to yield Aβ. Aβ molecules can aggregate to form oligomers (known as "seeds") which are believed to be able to induce other Aβ molecules to also take the misfolded oligomeric form, leading to a chain reaction akin to a prion infection. The seeds or the resulting amyloid plaques are toxic to nerve cells. The other protein implicated in Alzheimer's disease, tau protein, also forms such prion-like misfolded oligomers, and there is some evidence that misfolded Aβ can induce tau to misfold.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Antibody Type
Recombinant
Host Species
Rabbit
Immunogen
Recombinant fragment of human beta-amyloid 1-38
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/mL
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

Direct ELISA - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by ELISA assay. For Direct ELISA applications, a concentration of 31 ng/mL is recommended. It is recommended that the reagent be titrated for optimal performance for each application.

 

RRID
AB_2924612 (BioLegend Cat. No. 605452)

Antigen Details

Biology Area
Neurodegeneration, Neuroscience, Neuroscience Cell Markers
Molecular Family
APP/β-Amyloid
Antigen References
  1. Watts J, et al. 2014. Proc Natl Acad Sci U S A. 111:10323-8.
  2. Munter L, et al. 2010. J Biol Chem. 285:21636-43
Gene ID
351 View all products for this Gene ID
UniProt
View information about beta-Amyloid x-38 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 1    Revision Date: 05.09.2022

For research use only. Not for diagnostic use. Not for resale. BioLegend will not be held responsible for patent infringement or other violations that may occur with the use of our products.

 

*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, www.biolegend.com/ordering#license). BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products, reverse engineer functionally similar materials, or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.

 

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