- A18104E (See other available formats)
- Regulatory Status
- Other Names
- AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN-II, PN2, Amyloid beta A4 protein, preA4, protease nexin-II, peptidase nexin-II, beta-amyloid peptide, alzheimer disease amyloid protein, cerebral vascular amyloid peptide, APP, Amyloid Precursor Protein
- Mouse IgG2b, κ
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- Product Citations
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Alzheimer’s disease is characterized by the accumulation of aggregated amyloid beta (Aβ) peptides in senile plaques and vascular deposits. Aβ peptides are derived from amyloid precursor proteins (APP) through sequential proteolytic cleavage of APP by β-secretases and γ-secretases generating diverse Aβ species. Aβ can aggregate to form soluble oligomeric species and insoluble fibrillar or amorphous assemblies. Some forms of the aggregated peptides are toxic to neurons.Product Details
- Verified Reactivity
- Antibody Type
- Host Species
- Recombinant fragment of human β-Amyloid, 17-28
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- The antibody was purified by affinity chromatography.
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
IHC-P - Quality tested
WB - Verified
- Recommended Usage
Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry, a concentration range of 1.0 - 10.0 µg/mL is suggested. For western blotting, the suggested use of this reagent is 0.25 - 1.0 µg/mL. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
For use in immunohistochemistry, formic acid antigen retrieval is suggested.
This product is verified in Alzheimer’s disease brain lysate and recombinant human APP751 (Cat. No. 842601) by western blotting.
AB_2936738 (BioLegend Cat. No. 804601)
AB_2936738 (BioLegend Cat. No. 804602)
- Amyloid precursor protein is a 770 amino acid protein with a molecular mass of ~100 kD. According to the UniProtKB database, APP (ID# P05067) has 11 isoforms (34 to ~90 kD) and the 770 form has been designated as the canonical form. Isoform APP695 is the predominant form expressed in neuronal tissue. Isoforms APP751 and APP770 are widely expressed in non-neuronal cells. Isoform APP751 is the most abundant form in T-lymphocytes. Aβ denotes peptides of 36-43 amino acids generated from cleavage of APP by secretases. Aβ has an apparent molecular mass of about 4 kD.
Tissue distribution: Primarily nervous system, but also adipose tissue, intestine, and muscle.
Cellular distribution: Cytosol, endosomes, nucleus, plasma membrane, extracellular, and Golgi apparatus.
- The normal function of Aβ is not well understood. Several potential physiological roles have been proposed, including: activation of kinase enzymes, protection against oxidative stress, regulation of cholesterol transport, transcription factor, and as an anti-microbial agent.
- APBA and APBB family
- Biology Area
- Cell Biology, Neurodegeneration, Neuroscience, Protein Misfolding and Aggregation
- Molecular Family
- Antigen References
- Kumar A, et al. 2015. Pharmacol Rep. 67:195-203.
- Sadigh-Eteghad S, et al. 2015. Med Princ Pract. 24:1-10.
- Hampel H, et al. 2015. Expert Rev Neruother. 15:83-105.
- Puig KL, et al. 2013. Exp Gerontol. 48:608-11.
- Selkoe DJ, et al. 2016. EMBO Mol Med. 8:595-608.
- Walsh DM, et al. 2007. J Neurochem. 101(5):1172-84.
- Gene ID
- 351 View all products for this Gene ID
- View information about beta-amyloid 17-28 on UniProt.org
Related Pages & Pathways
Other FormatsView All β-amyloid 17-28 Reagents Request Custom Conjugation
|Purified anti-β-Amyloid, 17-28||A18104E||IHC-P,WB|
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