- Poly8119 (See other available formats)
- Regulatory Status
- Other Names
- Amyloid beta A4 protein, preA4, protease nexin-II, peptidase nexin-II, beta-amyloid peptide, alzheimer disease amyloid protein, cerebral vascular amyloid peptide, APP, Amyloid Precursor Protein
Signet Catalog# 9148-005
Covance Catalog# SIG-39148
- Rabbit Polyclonal IgG
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- Product Citations
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APP intracellular domain (AICD) is a peptide fragment that results from intramembraneous proteolysis of the amyloid precursor protein (APP). APP is a single-pass transmembrane protein that is involved in the pathophysiology of Alzheimer's disease (AD). APP is cleaved by gamma-secretase that releases the AICD into the cytoplasm. Soon after its release from the membrane, AICD is rapidly degraded in the cytoplasm partly by insulin degrading enzymes.Product Details
- Verified Reactivity
- Antibody Type
- Host Species
- Phosphate-buffered solution.
- The antibody was purified by affinity chromatography.
- 1.0 mg/mL
- Storage & Handling
- Do not store antibody diluted below 50 µg/mL in the absence of protein (i.e. add 2% bovine serum albumin). The antibody solution should be stored undiluted between 2°C and 8°C. Please note the storage condition for this antibody has been changed from -20°C to between 2°C and 8°C. You can also check your vial or your CoA to find the most accurate storage condition for this antibody.
ICC - Reported in the literature, not verified in house
- Recommended Usage
Each lot of this antibody is quality control tested by ELISA assay. For ELISA applications, a concentration range of 0.01 - 1 µg/mL is recommended. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
This antibody is specific for AICD (APP intracellular domain), which is a peptide fragment that results from the cleavage of C83 or C99 at the epsilon site. It does not react with the C57 or C59 γ-secretase cleavage products of APP.
This product may contain other non-IgG subtypes.
(PubMed link indicates BioLegend citation)
- Kaori K, et al. 2012. Invest Opththalmol Vis Sci. 53:7675-83. (WB)
- Stieren ES, et al. 2011. J Biol Chem. 286:35689-98. (WB)
- Tampellini D, et al. 2011. J Neurosci. 31:15384-90. (IF) PubMed
- Product Citations
AB_2564761 (BioLegend Cat. No. 811901)
- Biology Area
- Cell Biology, Neurodegeneration, Neuroscience, Protein Misfolding and Aggregation
- Molecular Family
- Gene ID
- 351 View all products for this Gene ID
- View information about AICD on UniProt.org
Related Pages & Pathways
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