PE anti-mouse IL-23R Antibody

Pricing & Availability
Clone
12B2B64 (See other available formats)
Regulatory Status
RUO
Other Names
Interleukin 23 Receptor, IL-23 Receptor, IL-23R, IBD17
Isotype
Rat IgG2b, κ
Ave. Rating
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Product Citations
publications
12B2B64_PE_IL23R_Antibody_032816
Th17-polarized cells from C57BL/6 mouse lymph nodes were stained with IL-23R (clone 12B2B64) PE (filled histogram) or rat IgG2b, κ PE isotype control (open histogram).
  • 12B2B64_PE_IL23R_Antibody_032816
    Th17-polarized cells from C57BL/6 mouse lymph nodes were stained with IL-23R (clone 12B2B64) PE (filled histogram) or rat IgG2b, κ PE isotype control (open histogram).
  • 12B2B64_PE_IL23R_Antibody_supplemental_052417
    IL-6 stimulated (3 days) C57BL/6 splenocytes were stained with IL-23R (clone 12B2B64) PE (filled histogram) or rat IgG2b, κ PE isotype control (open histogram).
See PE spectral data
Cat # Size Price Quantity Check Availability Save
150903 25 µg 100,00€
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150904 100 µg 220,00€
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Description

IL-23R is a 72 kD protein that associates with IL-12RB1 to form a heterodimer. It is a ligand for IL-23 and stimulates T, NK and some myeloid cells.  It is necessary for generation of Th17 cells but is not required for maintenance of previously generated Th17 cells.  Expression of IL-23R or mutations in the IL23R gene has been associated with autoimmunity and may also be important in tumor biology.

Product Details
Technical Data Sheet (pdf)

Product Details

Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
Partial mouse IL-23R recombinant protein (aa 24-374)
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
Concentration
0.2 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.5 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Product Citations
  1. Caughron B, et al. 2018. PLoS One. 13:e0196034. PubMed
  2. Wang L, et al. 2019. Cell Rep. 29:1848. PubMed
  3. Oguri Y, et al. 2020. Cell. 182(3):563-577.e20. PubMed
  4. Polese B, et al. 2021. Cell Reports. 36(4):109456. PubMed
  5. Luo X, et al. 2021. Neuron. 109(17):2691-2706.e5. PubMed
RRID
AB_2572188 (BioLegend Cat. No. 150903)
AB_2572189 (BioLegend Cat. No. 150904)

Antigen Details

Structure
72 kD protein that associates with IL-12RB1 to form a heterodimer.
Function
Involved in IL-23A signaling.
Interaction
JAK2 and STAT3.
Ligand/Receptor
IL-23/IL23A.
Biology Area
Immunology
Molecular Family
Cytokine/Chemokine Receptors
Antigen References

1. Parham C, et al. 2002. J. Immunol. 168:5699.
2. Schmechel S, et al. 2008. Inflamm. Bowel Dis. 14:204.
3. Harris TJ, et al. 2007. J. Immunol. 179:4313.
4. Zhang XY, et al. 2006. Immunogenetics 57:934.
5. Awasthi A, et al. 2009. J. Immunol. 182:5904.

Gene ID
209590 View all products for this Gene ID
UniProt
View information about IL-23R on UniProt.org

Related FAQs

What type of PE do you use in your conjugates?
We use R-PE in our conjugates.
Go To Top Version: 1    Revision Date: 03.28.2016

For research use only. Not for diagnostic use. Not for resale. BioLegend will not be held responsible for patent infringement or other violations that may occur with the use of our products.

 

*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, www.biolegend.com/ordering#license). BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products, reverse engineer functionally similar materials, or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.

 

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Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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