- 5G6 (See other available formats)
- Regulatory Status
- Other Names
- Sialic acid binding Ig-like lectin 10
- Mouse IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
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Siglec-10 is a lectin that specifically binds α-2,3- or α-2,6-linked sialic acid. It is a member of the Ig-superfamily and is expressed in monocytes, eosinophils, B cells, and a subset of NK cells. Siglec-10 is a single pass transmembrane protein. The extracellular domain contains one V-set Ig-like domain and three C2-set domains; the cytoplasmic domain contains one immunoreceptor tyrosine-based inhibitor motif (ITIM) which, after tyrosine-phosphorylation, recruits SH2-family phosphatases such as SHP-1 and PTPN6, resulting in the blocking of the signal transduction. CD24 and the vascular adhesion protein-1 (VAP-1) have been described as ligands of Siglec-10.Product Details
- Human, African Green
- Antibody Type
- Host Species
- Recombinant Siglec-10 fused to human IgG Fc
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA (origin USA).
- The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
- Lot-specific (please contact technical support for concentration and total µg amount, or use our Lookup tool if you have a lot number.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
FC - Quality tested
Agonist - Reported in the literature, not verified in house
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
- Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
(PubMed link indicates BioLegend citation)
- Munday J, et al. 2001. Biochem. J. 355:489
- Yokoi H, et al. 2006. Allergy. 61:769
- Kivi E, et al. 2009. Blood 114:5385
- Barkal AA, et al. 2019. Nature. 572(7769):392-396. (Agonist)
- Product Citations
AB_2270417 (BioLegend Cat. No. 347603)
AB_2189155 (BioLegend Cat. No. 347604)
- Lectin, belongs to the Ig-superfamily, has one V-set Ig-like domain and three C2-set domains, a single transmembrane domain and one immunoreceptor tyrosine-based inhibitor motif (ITIM) in the cytoplasmic domain
Monocytes, eosinophils, B cells, and a subset of NK cells
- Cell adhesion, signal transduction
- SHP-1, PTPN6
CD24, vascular adhesion protein-1 (VAP-1)
- Inhibition of signal transduction by recruiting cytoplasmic phosphatases
- Cell Type
- B cells, Eosinophils, Monocytes, NK cells
- Biology Area
- Molecular Family
- Siglec Molecules
- Antigen References
1. Chen GY, et al. 2009. Science 323:1722
2. Aizawa H, et al. 2003. Genomics.82:521
3. Kitzig F, et al. 2002. Biochem Biophys Res Commun. 296:355
- Gene ID
- 89790 View all products for this Gene ID
- View information about Siglec-10 on UniProt.org
- What type of PE do you use in your conjugates?
- We use R-PE in our conjugates.
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