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PE anti-human CXCL9 (MIG) Antibody

Pricing & Availability
Clone
J1015E10 (See other available formats)
Regulatory Status
RUO
Other Names
MIG-1, MIG
Isotype
Mouse IgG2a, κ
Ave. Rating
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Product Citations
publications
J1015E10_PE_CXCL9_Antibody_FC_041013
IFN-γ and TNF-α stimulated (overnight) human peripheral blood monocytes were intracellularly stained with CXCL9 (clone J1015E10) PE (filled histogram) or mouse IgG2a, κ PE isotype control (open histogram).
  • J1015E10_PE_CXCL9_Antibody_FC_041013
    IFN-γ and TNF-α stimulated (overnight) human peripheral blood monocytes were intracellularly stained with CXCL9 (clone J1015E10) PE (filled histogram) or mouse IgG2a, κ PE isotype control (open histogram).
Compare all formats See PE spectral data
Cat # Size Price Quantity Check Availability Save
357903 25 tests 113€
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357904 100 tests 278€
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Description

Chemokine (C-X-C motif) ligand 9 (CXCL9), also known as monokine induced by gamma interferon (MIG), is a small cytokine belonging to the non-ELR (lacking a Glu-Leu-Arg motif in the N-terminal region) motif CXC chemokines. CXCL9 shares the CXCR3 with CXCL10 and CXCL11, and these ligands differ in their receptor-binding and activating properties; CXCL11 is more potent than CXCL10 and CXCL10 is more potent than CXCL9. Some studies have revealed that these ligands have redundant functions in vivo; other studies have demonstrated that the three CXCR3 ligands can collaborate and even compete with each other.

CXCL9 is mainly produced by activated macrophages and some cancer cells. Functioning as a chemoattractant, CXCL9 attracts CXCR3-expressing cells (such as a subset of circulating T cells, B cells, and natural killer cells) into inflammatory sites. Like other chemokines, CXCL9 is also able to elicit intracellular calcium flux and activate PI3K and MAPK. It participates in multiple immune and inflammatory responses by affecting cell growth, movement, or activation.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Recombinant human CXCL9.
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

ICFC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Product Citations
  1. de Mingo Pulido , et al. 2021. Immunity. 54(6):1154-1167.e7. PubMed
RRID
AB_2562005 (BioLegend Cat. No. 357903)
AB_2562009 (BioLegend Cat. No. 357904)

Antigen Details

Structure
A member of the alpha subfamily of inflammatory chemokines.
Distribution
Activated macrophages and some cancer cells.
Function
Attracts CXCR3-expressing cells, such as a subset of circulating T cells, B cells, and natural killer cells.
Ligand/Receptor
CXCR3
Cell Type
Macrophages, B cells
Biology Area
Cell Biology, Immunology, Signal Transduction
Molecular Family
Cytokines/Chemokines
Antigen References

1. Groom JR, et al. 2012. Immunity 37:1091.
2. Loetscher P, et al. 2001. J. Biol. Chem. 276:2986.
3. Jones D, et al. 2000. Blood 95:627.
4. Liao F, et al. 1995. J. Exp. Med. 182:1301.

Gene ID
4283 View all products for this Gene ID
UniProt
View information about CXCL9 on UniProt.org

Related FAQs

What type of PE do you use in your conjugates?
We use R-PE in our conjugates.
Go To Top Version: 1    Revision Date: 04.25.2013

For research use only. Not for diagnostic use. Not for resale. BioLegend will not be held responsible for patent infringement or other violations that may occur with the use of our products.

 

*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, www.biolegend.com/ordering#license). BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products, reverse engineer functionally similar materials, or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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