- QA18A16 (See other available formats)
- Regulatory Status
- Other Names
- B7-1, B7, BB1
- Mouse IgG1, κ
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- Product Citations
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CD80, also known as B7-1, B7, and BB1, is a 60 kD single chain type I glycoprotein belonging to the immunoglobulin superfamily. CD80 is expressed on activated B and T cells, macrophages, and dendritic cells. CD80 binds to CD28 and CD152 (CTLA-4). Along with CD86, CD80 plays a critical role in regulation of T cell activation. The interaction of CD80 with CD28 provides a potent costimulatory signal for T cell activation through the CD3 complex, while its interaction with CTLA-4 provides an inhibitory signal for T cell activation.Product Details
- Antibody Type
- Host Species
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA (origin USA)
- The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
- Lot-specific (please contact technical support for concentration and total µg amount, or use our Lookup tool if you have a lot number.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
- Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
AB_2890803 (BioLegend Cat. No. 370611)
AB_2890803 (BioLegend Cat. No. 370612)
- Ig superfamily, single chain type I transmembrane glycoprotein, 60 kD
- T cell costimulation
- CD28, CD152 (CTLA-4)
- Antigen References
- Good-Jacobson KL, et al. 2012. J Immunol. 188:4217-25.
- Kleinpeter P, et al. 2019. J Virol. 93:e00207-19.
- Haile ST, et al. 2014. Cancer Immunol Res. 2:610-5.
- Gene ID
- 941 View all products for this Gene ID
- View information about CD80 on UniProt.org
- What type of PE do you use in your conjugates?
- We use R-PE in our conjugates.
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