- TX45 (See other available formats)
- Regulatory Status
- Other Names
- LIR, CLM-6, CMRF35, IGSF16, CMRF-35, CMRF35A, CMRF-35A, CMRF35A1, CMRF35-A1
- Mouse IgG1, κ
- Ave. Rating
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- Product Citations
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CD300c, also known as CMRF-35-like molecule 6 (CLM-6) and leukocyte immunoglobulin-like receptor (LIR) is a 25 kD protein that belongs to the myeloid-associated immunoglobulin-like receptor (MAIR) family of genes. This transmembrane protein is expressed on certain B cells, T cells, NK cells, granulocytes, macrophages, monocytes, and mast cells. CD300C promotes secretion of proinflammatory cytokines and is an activating immune receptor associated ITAM-bearing adapter DAP12 and FcRγ chain on macrophages.Product Details
- Human, African Green, Baboon, Cynomolgus, Rhesus
- Antibody Type
- Host Species
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA (origin USA).
- The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
- Lot-specific (please contact technical support for concentration and total µg amount, or use our Lookup tool if you have a lot number.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
- Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
(PubMed link indicates BioLegend citation)
- Simhadri VR, et al. 2013. J. Innate Immun. 4:389.
- Product Citations
AB_2208159 (BioLegend Cat. No. 334804)
- Ig superfamily, 40 kD
- Monocytes/macrophages, dendritic cells
- Regulate myeloid cell activation and promote secretion of cytokines and chemokines
- DAP12, FcRγ
- Cell Type
- Monocytes, Macrophages, Dendritic cells
- Biology Area
- Immunology, Innate Immunity
- Molecular Family
- CD Molecules
- Antigen References
1. Borrego F. 2013. Blood 11:1951.
2. Ju X, et al. 2009. Immunobiology 730-736.
3. Simhadri, et al. 2011. BMC Immunology 12:62.
- Gene ID
- 10871 View all products for this Gene ID
- View information about CD300c on UniProt.org
- What type of PE do you use in your conjugates?
- We use R-PE in our conjugates.
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