PE anti-human CD221 (IGF-1R) Antibody

Pricing & Availability
1H7/CD221 (See other available formats)
Regulatory Status
Other Names
Insulin-like growth factor 1 receptor (IGF1R)
Mouse IgG1, κ
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Product Citations
Human peripheral blood lymphocytes were stained with CD3 APC and CD221 (clone 1H7/CD221) PE (top) or mouse IgG1 PE isotype control (bottom).
  • 1H7slashCD221_PE_1_042211
    Human peripheral blood lymphocytes were stained with CD3 APC and CD221 (clone 1H7/CD221) PE (top) or mouse IgG1 PE isotype control (bottom).
  • 1H7slashCD221_PE_2_042211
See PE spectral data
Cat # Size Price Quantity Check Availability Save
351805 25 tests 108€
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351806 100 tests 244€
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CD221, also known as insulin-like growth factor 1 receptor (IGF1R), is a 135 kD transmembrane receptor. It is widely expressed on lymphoid and myeloid cells as well as non-haematopoietic cells. CD221 is a tyrosine kinase receptor and the ligands for CD221 are insulin-like growth factor 1 and 2 (IGF-1 and IGF-2), the polypeptide hormones similar in molecular structure to insulin. IGF-1/2 binding activates downstream PI3K and MAPK pathways and plays an important role in cell growth. Recent studies reveal its function of recruiting immune cells during tissue repair.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Reported Reactivity
African Green, Baboon, Cynomolgus, Rhesus
Antibody Type
Host Species
IGF-1 receptor purified from human placentas
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application Notes

This clone has been published as 1H7. Additional reported applications (for the relevant formats) include: Western blotting1, immunoprecipitation1, immunohistochemical staining of frozen tissue sections2, and blocking functions2-5.

This product is offered for sale and sold pursuant to a license to seller by City of Hope and may be used only as a research reagent.  Use for any other purpose is expressly not authorized.

Application References

(PubMed link indicates BioLegend citation)
  1. Li SL, et al. 1993. Biochem. Bioph. Res. Co. 196:92. (WB IP)
  2. Li SL, et al. 2000. Cancer Immunol. Immun. 49:243. (IHC Block)
  3. Ye JJ, et al. 2003. Horm. Metab. Res. 35:836. (Block)
  4. Kusada Y, et al. 2008. J. Biochem. 143:9. (Block)
  5. Ohtani M, et al. 2009. Biosci. Trends. 3:131. (Block)
Product Citations
  1. Bitton A, et al. 2021. Cytometry A. . PubMed
  2. Pasternack J, et al. 2014. J Nucl Med. 55:2012. PubMed
AB_10900986 (BioLegend Cat. No. 351805)
AB_10895918 (BioLegend Cat. No. 351806)

Antigen Details

IGF-1R contains 2 α subunits and 2 β subunits, 135 kD

Haematopoietic cells and non-haematopoietic cells

Cell growth and immune cells recruitment
IGF-1, IGF-2
Biology Area
Cell Biology, Immunology
Molecular Family
CD Molecules
Antigen References

1. Baudler S, et al. 2005. J. Immunol. 174:5516.
2. Sharp LL, et al. 2005. Nat. Immunol. 6:73.

Gene ID
3480 View all products for this Gene ID
View information about CD221 on

Related FAQs

What type of PE do you use in your conjugates?
We use R-PE in our conjugates.
Go To Top Version: 1    Revision Date: 11.30.2012

For research use only. Not for diagnostic use. Not for resale. BioLegend will not be held responsible for patent infringement or other violations that may occur with the use of our products.


*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products, reverse engineer functionally similar materials, or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.


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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

  • Purified anti-human CD221 (IGF-1R)

  • PE anti-human CD221 (IGF-1R)


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