PE anti-human CD161 Antibody

Pricing & Availability
HP-3G10 (See other available formats)
Regulatory Status
Other Names
Mouse IgG1, κ
Ave. Rating
Submit a Review
Product Citations
Human peripheral blood lymphocytes stained with CD4 FITC and HP-3G10 PE
  • A_HP-3G10_PE_022309.jpg
    Human peripheral blood lymphocytes stained with CD4 FITC and HP-3G10 PE
  • B_HP-3G10_PE_022309.jpg
    Human peripheral blood CD4+ lymphocytes stained with CCR6 PerCP/Cy5.5 and HP-3G10 PE
Compare all formats See PE spectral data
Cat # Size Price Quantity Check Availability Save
339903 25 tests 93€
Check Availability

Need larger quantities of this item?
Request Bulk Quote
339904 100 tests 202€
Check Availability

Need larger quantities of this item?
Request Bulk Quote
339938 100 µg 224€
Check Availability

Need larger quantities of this item?
Request Bulk Quote

CD161 is a type II transmembrane glycoprotein, also known as NKR-P1A, that is expressed as a 40-44 kD homodimer. It is a member of the C-type lectin superfamily. CD161 is expressed on a majority of NK cells, NKT cells, and subsets of peripheral T cells and CD3+ thymocytes. It has been reported that Th17 cells are a subpopulation of CD4+CD161+CCR6+ cells. While the biological function of CD161 is not clear, it has been suggested to serve either as a stimulatory receptor or to inhibit NK cell-mediated cytotoxicity and cytokine production. LLT-1 (lectin-like transcript-1, also named as osteoclast inhibitory lectin or CLEC2D) is the ligand of CD161.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human, Cynomolgus, Rhesus
Reported Reactivity
African Green, Baboon
Antibody Type
Host Species
Human NK cells
µg size: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
test sizes: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA).
The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
µg sizes: 0.2 mg/mL
test sizes: lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining using the µg size, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application. For flow cytometric staining using the test sizes, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application Notes

Additional reported applications (for the relevant formats) include: inhibition of cytokine production and Western blotting under nonreducing conditions.

Application References

(PubMed link indicates BioLegend citation)
  1. Gumß M, et al. 2004. Blood 104:3664.
  2. Exley M, et al. 1998. J. Exp. Med. 188:867.
  3. Marquez C, et al. 1998. Blood 91:2760.
Product Citations
  1. Ibidapo-Obe O, et al. 2020. Cell Mol Gastroenterol Hepatol. 9:661. PubMed
  2. Liu C, et al. 2021. Cell Res. 31:1106. PubMed
  3. Goetzl E, et al. 2010. FASEB J. 24:3580. PubMed
  4. Nicholas DA et al. 2019. Cell Metab. 30(3):447-461 . PubMed
  5. Bergamaschi L, et al. 2021. Immunity. 54(6):1257-1275.e8. PubMed
  6. Holm A, et al. 2017. Immun Inflamm Dis. 10.1002/iid3.188. PubMed
  7. Yang R, et al. 2020. Cell. 183(7):1826-1847.e31. PubMed
  8. Zhao L, et al. 2016. Rheumatology. 10.1093/rheumatology/kew360. PubMed
  9. Morimoto Y, et al. 2018. Immunity. 49:134. PubMed
  10. COOSEMANS A, et al. 2013. Anticancer Res. 33:5495. PubMed
  11. Golebski K, et al. 2021. Immunity. 54(2):291-307.e7. PubMed
  12. Liu Y, et al. 2020. Methods Mol Biol. 2111:285. PubMed
  13. Bal S, et al. 2016. Nat Immunol. 10.1038/ni.3444. PubMed
  14. Yang Zhou J, et al. 2022. Front Immunol. 13:898473. PubMed
  15. Tang X, et al. 2020. Sci Adv. 6:eaaz0374. PubMed
AB_1501086 (BioLegend Cat. No. 339903)
AB_1501083 (BioLegend Cat. No. 339904)
AB_2564141 (BioLegend Cat. No. 339938)

Antigen Details

Type II glycoprotein, 40-44 kD homodimer, C-type lectin superfamily

NK cells, T subset, subset of CD3+ thymocytes

LLT-1 (Lectin-like transcript-1)
Cell Type
NK cells, T cells, Thymocytes
Biology Area
Cell Biology, Immunology, Innate Immunity, Signal Transduction
Molecular Family
CD Molecules
Antigen References

1. Takahashi T, et al. 2006. J. Immunol. 176:211.
2. Cosmi L, et al. 2008. J. Exp. Med. 205:1903.
3. Aldemir H, et al. 2005. J. Immunol. 175:7791.
4. Rosen DB, et al. 2008. J. Immunol. 180:6508.

Gene ID
3820 View all products for this Gene ID
View information about CD161 on

Related FAQs

What type of PE do you use in your conjugates?
We use R-PE in our conjugates.
Go To Top Version: 1    Revision Date: 11.30.2012

For research use only. Not for diagnostic use. Not for resale. BioLegend will not be held responsible for patent infringement or other violations that may occur with the use of our products.


*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products, reverse engineer functionally similar materials, or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.


BioLegend Inc., 8999 BioLegend Way, San Diego, CA 92121
Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

  • Brilliant Violet 510™ anti-human CD161

  • FITC anti-human CD161

  • Purified anti-human CD161

  • PE anti-human CD161

  • PerCP/Cyanine5.5 anti-human CD161

  • Alexa Fluor® 647 anti-human CD161

  • APC anti-human CD161

  • Brilliant Violet 421™ anti-human CD161

  • Brilliant Violet 605™ anti-human CD161

  • PE/Cyanine7 anti-human CD161

  • Alexa Fluor® 700 anti-human CD161

  • Purified anti-human CD161 (Maxpar® Ready)

  • Alexa Fluor® 488 anti-human CD161

  • Pacific Blue™ anti-human CD161

  • APC/Cyanine7 anti-human CD161

  • Brilliant Violet 785™ anti-human CD161

  • Biotin anti-human CD161

  • PerCP anti-human CD161

  • PE/Dazzle™ 594 anti-human CD161

  • APC/Fire™ 750 anti-human CD161

  • TotalSeq™-A0149 anti-human CD161

  • TotalSeq™-C0149 anti-human CD161

  • TotalSeq™-B0149 anti-human CD161

  • PE/Cyanine5 anti-human CD161 Antibody

  • TotalSeq™-D0149 anti-human CD161

  • Spark Red™ 718 anti-human CD161


Login / Register
Remember me
Forgot your password? Reset password?
Create an Account