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PE anti-human CD126 (IL-6Rα) Antibody

Pricing & Availability
Clone
UV4 (See other available formats)
Regulatory Status
RUO
Other Names
IL-6R1, gp80, IL-6 receptor alpha, IL-6R
Isotype
Mouse IgG1, κ
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Product Citations
publications
UV4_PE_1_082911
Human peripheral blood lymphocytes were stained with CD3 APC and IL-6Rα (clone UV4) PE (top) or mouse IgG1, κ PE isotype control (bottom).
  • UV4_PE_1_082911
    Human peripheral blood lymphocytes were stained with CD3 APC and IL-6Rα (clone UV4) PE (top) or mouse IgG1, κ PE isotype control (bottom).
  • UV4_PE_2_082911
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352803 25 tests 104€
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352804 100 tests 268€
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Description

CD126 is an 80 kD IL-6 receptor α chain also known as IL-6R. It is a member of the immunoglobulin superfamily that is expressed on plasma cells, T cells, activated B cells, monocytes, granulocytes, hepatocytes, epithelial cells, and fibroblasts. Functional IL-6 receptors are formed by the non-covalent association of CD126 and the IL-6 receptor β chain (CD130 or gp130). CD126 binds IL-6 with low affinity but does not signal. The β chain (gp130, CD130) does not bind IL-6 by itself but associates with the α-chain/IL-6 complex to initiate signal transduction. IL-6 binding to the receptor complex results in the stimulation of B and T cells, and hematopoietic precursor proliferation and differentiation. A soluble form of CD126 has been found in human serum.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Reported Reactivity
African Green, Baboon, Cynomolgus, Rhesus
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Human myeloma cell line U266
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application Notes

Additional reported applications (for the relevant formats) include: blocking of IL-6 binding to IL-6R.

Application References

(PubMed link indicates BioLegend citation)
  1. Huang YW and Vitetta ES. 1993. Hybridoma 12:621.
Product Citations
  1. Csomós I, et al. 2021. Int J Mol Sci. 22:. PubMed
  2. Zhang G, et al. 2020. Am J Transplant. 20:999. PubMed
  3. Ferreira R, et al. 2013. PLoS Genet. 9:1003444. PubMed
  4. Eriksson E, et al. 2016. Gene Ther. 10.1038/gt.2016.80. PubMed
  5. Perrigue P, et al. 2015. Mol Cancer Res. 13:636. PubMed
  6. Eriksson E, et al. 2019. J Immunol. 202:787. PubMed
  7. Saga R, et al. 2019. Oncol Lett. 17:3555. PubMed
  8. Van Zeebroeck L, et al. 2021. Front Immunol. 12:655122. PubMed
  9. Alasady MJ, et al. 2021. PLoS One. 16:e0256238. PubMed
  10. Salameh JW, et al. 2022. Bioengineering (Basel). 9:. PubMed
RRID
AB_10897103 (BioLegend Cat. No. 352803)
AB_10900066 (BioLegend Cat. No. 352804)

Antigen Details

Structure
Ig superfamily, associates with IL-6Rβ chain (CD130, gp130), 80 kD
Distribution

Plasma cells, T cells, monocytes, hepatocytes, activated B cells, granulocytes, epithelial cells, and fibroblasts

Function
Stimulates T cells, B cells, and hematopoietic precursor proliferation and differentiation
Interaction
CD130, c-Src, STAT3, WWP1, WWP2
Ligand/Receptor
IL-6
Cell Type
B cells, Epithelial cells, Fibroblasts, Granulocytes, Monocytes, Plasma cells, T cells
Biology Area
Cell Biology, Immunology, Innate Immunity, Neuroinflammation, Neuroscience, Signal Transduction
Molecular Family
CD Molecules, Cytokine/Chemokine Receptors
Antigen References

1. Taga T, et al. 1997. Annu. Rev. Immunol. 15:797.
2. Fitzgerald K, et al. 2001. The Cytokine FactsBook. Academic Press London.
3. Boulanger MJ, et al. 2003. Science 300:2101.
4. Gaillard JP, et al. 1993. Eur. J. Immunol. 23:820.

Gene ID
3570 View all products for this Gene ID
UniProt
View information about CD126 on UniProt.org

Related FAQs

What type of PE do you use in your conjugates?
We use R-PE in our conjugates.
Go To Top Version: 1    Revision Date: 11.30.2012

For research use only. Not for diagnostic use. Not for resale. BioLegend will not be held responsible for patent infringement or other violations that may occur with the use of our products.

 

*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, www.biolegend.com/ordering#license). BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products, reverse engineer functionally similar materials, or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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