- 346-11A (See other available formats)
- Regulatory Status
- Other Names
- Integrin β4, β4 integrin, TSP-1180, ITGB4
- Rat IgG2a, κ
- Ave. Rating
- Submit a Review
- Product Citations
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CD104 is a 205 kD type I transmembrane glycoprotein, also known as integrin β4 chain or β4 integrin, that associates with integrin α6 (CD49f) to form the α6/β4 (CD49f/CD104) heterodimer. CD104 is expressed on epithelial cells (especially on proliferative basal layer epithelial cells in skin), endothelial cells, Schwann cells, certain tumor cells, and a subset of pre-T cells. The CD49f/CD104 heterodimer is an adhesion receptor for laminins (especially laminin 5) and keratin filaments, and is involved in the regulation of hemidesmosome formation and cell proliferation and activation.Product Details
- Verified Reactivity
- Antibody Type
- Host Species
- Tumor-associated antigen TSP-180 from BALB/c lung carcinoma
- Phosphate buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography, and conjugated with FITC under optimal conditions.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Excitation Laser
Blue Laser (488 nm)
- Application Notes
Additional reported (for the relevant formats) applications include: immunohistochemical staining1.
(PubMed link indicates BioLegend citation)
- Tennenbaum T, et al. 1993. Cancer Res. 53:4803. (IHC)
- Product Citations
AB_2234035 (BioLegend Cat. No. 123605)
AB_2129036 (BioLegend Cat. No. 123606)
- Integrin β chain, 205 kD, forms heterodimer with integrin α6 (CD49f)
Epithelial cells, endothelial cells, some tumor cells, pre-T cell subset
- Laminins, keratin filaments
- Cell Type
- Embryonic Stem Cells, Endothelial cells, Epithelial cells, T cells
- Biology Area
- Cell Adhesion, Cell Biology, Immunology, Stem Cells
- Molecular Family
- Adhesion Molecules, CD Molecules
- Antigen References
1. Kennel SJ, et al. 1992. J. Cell Sciences 101:1992.
- Gene ID
- 192897 View all products for this Gene ID
- View information about CD104 on UniProt.org
|PerCP/Cyanine5.5 anti-mouse CD104||346-11A||FC|
|PE/Cyanine7 anti-mouse CD104||346-11A||FC|
|APC anti-mouse CD104||346-11A||FC|
|TotalSeq™-C1028 anti-mouse CD104||346-11A||PG|
|TotalSeq™-B1028 anti-mouse CD104||346-11A||PG|
|Purified anti-mouse CD104||346-11A||FC, IP, ELISA|
|Biotin anti-mouse CD104||346-11A||FC|
|FITC anti-mouse CD104||346-11A||FC|
|Alexa Fluor® 647 anti-mouse CD104||346-11A||FC|
|PE anti-mouse CD104||346-11A||FC|
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