- A8 (See other available formats)
- Regulatory Status
- Other Names
- Mouse IgG1, κ
- Ave. Rating
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- Product Citations
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CD100, a 150 kD homodimer, is a novel semaphorin that induces B cells to aggregate and improves their viability in vitro. Semaphorins are neuronal chemorepellants that direct pioneering neurons during nervous system development. CD100 modifies CD40-CD40L B cell signaling by augmenting B cell aggregation and survival and down regulating CD23 expression. CD72 is a lymphocyte receptor for the class IV semaphorin CD100, which is involved in regulating B cell signaling. CD100 is expressed on resting and PHA stimulated T cells. The protein is weakly expressed on NK cells, EBV transformed B cells, monocytes and tumor/peripheral blood T cell lines, and at higher density on activated T cells and B cells.Product Details
- Human, African Green, Baboon, Cynomolgus, Rhesus
- Antibody Type
- Host Species
- Human PHA activated lymphocytes
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA (origin USA).
- The antibody was purified by affinity chromatography, and conjugated with FITC under optimal conditions.
- Lot-specific (please contact technical support for concentration and total µg amount, or use our Lookup tool if you have a lot number.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
- Excitation Laser
Blue Laser (488 nm)
(PubMed link indicates BioLegend citation)
- Hall K, et al. 1996. P. Natl. Acad. Sci. USA 93:11780.
- Mizrahi S, et al. 2007. PLoS One. 2(9):e818.
- Yoshino N, et al. 2000. Exp. Anim. (Tokyo) 49:97. (FC)
- Product Citations
AB_2254362 (BioLegend Cat. No. 328406)
- Class IV semaphorin family member, 150 kD homodimer
T cells, B cells, weak on NK cells
- Costimulatory molecule in adaptive immune responses that switches off negative signaling from CD72
- Cell Type
- T cells, B cells, NK cells
- Biology Area
- Molecular Family
- CD Molecules
- Antigen References
1. Schlossman SL Bloumsell W Gilks et al. eds. 1995. Leucocyte Typing V:White Cell Differentiation Antigens. Oxford University Press New York.
2. Bougeret CIG Mansur H Dastot et al. 1992. Increased surface expression of a newly identified 150 kDa dimer early afterhuman T lymphocyte activation. J. Immunol. 148:318.
3. Knapp WB Dorken EP. Rieber et al, eds. 1989. Leucocyte Typing IV:White Cell Differentiation Antigens. Oxford University Press New York.
- Gene ID
- 10507 View all products for this Gene ID
- View information about CD100 on UniProt.org
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