Biotin anti-human β2-microglobulin Antibody

Pricing & Availability
2M2 (See other available formats)
Regulatory Status
Other Names
β2M, β2-M, beta2-microglobulin b2-M, b2M
Mouse IgG1, κ
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Product Citations
Human peripheral blood lymphocytes stained with biotinylated 2M2, followed by Sav-PE
  • 2M2_Biotin_072307
    Human peripheral blood lymphocytes stained with biotinylated 2M2, followed by Sav-PE
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316308 100 µg 156,00€
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β2-microglobulin (β2M) is a 12 kD nonpolymorphic Ig like protein. It is a non-membrane-anchored glycoprotein and is noncovalently associated with 39-44 kD polymorphic heavy chains of MHC class I molecules to form HLA class I antigen complex. In association with HLA class I, β2M is expressed on all leukocytes, platelets, endothelial cells, and epithelial cells. β2M plays an essential role both in governing MHC class I molecules stability and in promoting antigen binding and presenting the antigen to CD3/TCR complex of CD8+ T cells.

Product Details
Technical Data Sheet (pdf)

Product Details

Human, African Green, Baboon, Cynomolgus, Rhesus, Swine (Pig, Porcine)
Antibody Type
Host Species
Purified human β2-microglobulin
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
The antibody was purified by affinity chromatography, and conjugated with biotin under optimal conditions.
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C. Do not freeze.

FC - Quality tested

Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.5 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

Additional reported applications (for the relevant formats) include: Western blotting, and ELISA.

Application References

(PubMed link indicates BioLegend citation)
  1. Meissner TB, et al. 2010. Proc Natl Acad Sci USA. PubMed
  2. Rizvi SM, et al. 2011. J. Immunol. 186:2309. PubMed
  3. Meissner TB, et al. 2012. J Immunol. 188:4951. PubMed.
Product Citations
  1. Tischer DK et al. 2019. eLife. 8 pii: e42498. PubMed
  2. Mendoza JL, et al. 2020. eLife. 9:00. PubMed
AB_493689 (BioLegend Cat. No. 316308)

Antigen Details

Nonpolymorphic Ig like structure, noncovalently associated with heavy chain of MHC class I molecules, 12 kD

Leukocytes, platelets, endothelial cells, epithelial cells

Govern MHC class I molecule stability, promote MHC class I molecules binding and presenting peptide antigens to CD8+ T cells
CD3/TCR complex, CD8
Cell Type
Leukocytes, Platelets, Endothelial cells, Epithelial cells
Biology Area
Molecular Family
MHC Antigens
Antigen References

1. Engelhard VH. 1994. Curr. Opin. Immunol. 6:13.
2. Williams DB, et al. 1989. J. Immunol. 142:2796.
3. Danliczyk UG and TL. Delovitch. 1994. J. Immunol. 153:3533.
4. Williams A, et al. 2002. Tissue Antigens 59:3.

Gene ID
567 View all products for this Gene ID
View information about beta2-microglobulin on

Related FAQs

How many biotin molecules are per antibody structure?
We don't routinely measure the number of biotins with our antibody products but the number of biotin molecules range from 3-6 molecules per antibody.
Go To Top Version: 2    Revision Date: 11.15.2016

For research use only. Not for diagnostic use. Not for resale. BioLegend will not be held responsible for patent infringement or other violations that may occur with the use of our products.


*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products, reverse engineer functionally similar materials, or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.


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Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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