- UC3-10A6 (See other available formats)
- Regulatory Status
- Other Names
- Vγ2 T-cell receptor, T cell receptor gamma 2
- Armenian hamster IgG
- Ave. Rating
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- Product Citations
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T cell receptor (TCR) Vγ2 bearing T lymphocytes make up a significant proportion of γδ TCR cells in late fetal and adult peripheral lymphoid tissues. TCR γδ T cells may play a role in immunological surveillance for stress-induced self-antigens. The frequency of Vγ2 expression in different strains varied from 12% to 54% in the TCR γδ repertoire. Variations in the levels of Vγ2+ cells are not associated with MHC haplotype. High Vγ2 expression is influenced by the TCR-δ locus. Expanding Vγ2+ TCRγδ cells in B6 mice overwhelmingly use a Vδ7+ δ chain except in the DBA/2 strain. Clone UC3-10A6 reacts with the Vγ2 segment as designated by the Garman nomenclature1.Product Details
- Antibody Type
- Host Species
- Armenian Hamster
- G8 mouse T cells
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
- 0.2 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.125 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Excitation Laser
Red Laser (633 nm)
(PubMed link indicates BioLegend citation)
- Dent AL, et al. 1990. Nature 343:714.
- Kelly KA, et al. 1993. Int. Immunol. 5:331.
- Sperling AI, et al. 1992. J. Immunol. 149:3200.
- Sperling AI, et al. 1997. J. Immunol. 159:86.
- Product Citations
AB_10899574 (BioLegend Cat. No. 137707)
AB_10897644 (BioLegend Cat. No. 137708)
- A member of Ig superfamily, associated with TCR δ chain and CD3 complex.
T cell subset in fetal and adult peripheral lymphoid tissues and thymus.
- Might play a role in a previously unrecognized form of immunological surveillance for stress-induced self-antigens.
- Cell Type
- T cells
- Biology Area
- Adaptive Immunity, Immunology
- Molecular Family
- Antigen References
1. Allison JP, et al. 1991. Annu. Rev. Immunol. 9:679.
2. O’Brien RL, et al. 2000. J. Immunol. 165:6472.
- Gene ID
- 110067 View all products for this Gene ID
- View information about TCR Vgamma2 on UniProt.org
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