- UP-D2 (See other available formats)
- Regulatory Status
- Other Names
- CD300LF, IREM-1, IgSF13
- Mouse IgG1, κ
- Ave. Rating
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- Product Citations
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IREM-1 (immune receptor expressed by myeloid cell 1) is a type I single transmembrane protein encoded by human chromosome 17q24.25. A member of the CD300 (CMRF-35) family and the Ig superfamily, IREM-1 is also known as CD300F, or CD300LF (CD300-like member F). CD300F is expressed on monocytes, granulocytes, and myeloid leukemia cell lines. The cytoplasmic domain of IREM-1 contains an ITIM and associates with the P85α subunit of PI3K (phosphoinositide 3-kinase). IREM-1 also functions as an inhibitory receptor.Product Details
- Antibody Type
- Host Species
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA (origin USA).
- The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
- Lot-specific (please contact technical support for concentration and total µg amount, or use our Lookup tool if you have a lot number.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
FC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
- Excitation Laser
Red Laser (633 nm)
- Application Notes
Additional reported applications include: Coengagement of IREM-1 with UP-D2 inhibits FcReI-mediated degranulation, immunoprecipitation
(PubMed link indicates BioLegend citation)
- Alvarez-Errico D, et al. 2004. Eur. J. Immunol. 34:3690
- Lee SM, et al. 2011. J. Immunol. 186:6296. PubMed.
- Product Citations
AB_2728305 (BioLegend Cat. No. 340605)
AB_2728306 (BioLegend Cat. No. 340606)
- Type I single transmembrane protein with cytoplamic ITIM, associates with p85α of PI3K, Ig superfamily
Monocytes, granulocytes, and myeloid leukemia cell lines
- Inhibition of myeloid function
- Cell Type
- Monocytes, Granulocytes, Leukemia
- Biology Area
- Molecular Family
- CD Molecules
- Antigen References
1. Marquez JA, et al. 2007. J. Mol. Bio. 367:310
2. Alvarez-Errico D, et al. 2004. Eur. J. Immunol. 34:3690
3. Alvarez-Errico D, et al. 2007. J. Immunol. 178:808
- Gene ID
- 146722 View all products for this Gene ID
- View information about CD300F on UniProt.org
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