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APC anti-human CD268 (BAFF-R, BAFFR) Antibody

Pricing & Availability
Clone
11C1 (See other available formats)
Regulatory Status
RUO
Other Names
TNFRSF13C, BAFF-R, BAFFR, BR3, BAFF Receptor
Isotype
Mouse IgG1, κ
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Product Citations
publications
11C1_APC_CD268_Antibody_FC_1_011515
Human peripheral blood lymphocytes stained with CD19 (HIB19) FITC and CD268 (11C1) APC (top) or mouse IgG1, κ APC isotype control (bottom).
  • 11C1_APC_CD268_Antibody_FC_1_011515
    Human peripheral blood lymphocytes stained with CD19 (HIB19) FITC and CD268 (11C1) APC (top) or mouse IgG1, κ APC isotype control (bottom).
  • 11C1_APC_CD268_Antibody_FC_2_011515
Compare all formats See APC spectral data
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316916 100 tests 237€
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Description

B cell-activating factor receptor (BAFF-R) is a 19 kD type III membrane protein. It belongs to TNFR superfamily, also known as TNFRSF member 13C (TNFRSF13C), BAFF receptor 3 (BR3), or CD268. BAFF-R is expressed on mature B cells, B cell lymphoma, and T cell subset. BAFF-R is the major receptor for BAFF/BLys (or TALL-1, THANK) which binds to TACI and BCMA as well. The interaction of BAFF with BAFF-R promotes NF-κB activation and plays predominant roles in B-cell maturation and survival as well as costimulates T cell activation and proliferation. TRAF3 is a BAFF-R intracellularly associated protein, which negatively regulates BAFF-R-mediated NF-κB activation.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Reported Reactivity
African Green, Baboon, Cynomolgus, Rhesus
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
BAFF-R-L1.2 transfectants
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

Excitation Laser
Red Laser (633 nm)
Application References

(PubMed link indicates BioLegend citation)
  1. Ng LG, et al.2004. J. Immunol. 173:807. (FC IHC)
  2. Personal communication. (Block)
Product Citations
  1. Madayag K, et al. 2022. Immun Inflamm Dis. 10:e729. PubMed
  2. Pontarini E, et al. 2015. Rheumatology. 54: 1429-1434. PubMed
  3. Parackova Z, et al. 2017. Immunol Lett. 10.1016/j.imlet.2017.04.009. PubMed
  4. Aggarwal C, et al. 2021. J Virol. 95:e0061021. PubMed
RRID
AB_10663404 (BioLegend Cat. No. 316916)

Antigen Details

Structure
Type III transmembrane protein, TNF receptor superfamily, 19 kD
Distribution

Mature B cells, B cell lymphoma, T cell subset

Function
Induce B cell proliferation and immunoglobulin secretion, costimulate T cell activation
Ligand/Receptor
BAFF/BLys, associate with TRAF3
Cell Type
B cells, Leukemia, T cells
Biology Area
Immunology
Molecular Family
CD Molecules
Antigen References

1. Thompson JS, et al. 2001. Science 293:2108.
2. Ng LG, et al.2004. J. Immunol. 173:807.
3. Rodig SJ, et al. 2005. Human Pathol. 36:1113.
4. Ye Q, et al. 2004. Eur. J. Immunol. 34:2750.
5. Kayagaki N, et al. 2002 Immunity 17:515.

Gene ID
115650 View all products for this Gene ID
UniProt
View information about CD268 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 1    Revision Date: 11.30.2012

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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