Anti-Presenilin 2 Antibody (Previously Covance catalog# MMS-359S)

Pricing & Availability
PS2 (See other available formats)
Regulatory Status
Other Names
Presenilin-2, AD5, E5-1, PS-2, AD3LP, STM-2, gamma-secretase, PSEN2, PS2
Covance Catalog# MMS-359S
Mouse IgG1, κ
Ave. Rating
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Product Citations
Western blot using Clone PS2 to detect both endogenous PS2 in HEK293 cells and transfected Human PS2 in another cell line. Photo courtesy of P. Fraser.
  • PS2_TCS_Presenilin2_Antibody_WB_030315
    Western blot using Clone PS2 to detect both endogenous PS2 in HEK293 cells and transfected Human PS2 in another cell line. Photo courtesy of P. Fraser.
Cat # Size Price Quantity Avail. Save
814201 1 mL 225,00€
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Mutations in the genes for presenilin 1 and 2 (PS1/PS2) are the causative factors for ~50% of early onset familial Alzheimer's disease. PS1 and PS2 are homologous transmembrane proteins, and along with nicastrin, form high molecular mass multimeric protein complexes involved in the intramembranous proteolysis of several proteins including beta amyloid precursor protein (β-APP) and Notch receptor. Absence of PS1 is associated with dramatic reductions in the levels of mature glycosylated nicastrin. In contrast, absence of PS2 is associated with only modest reductions in the levels of immature nicastrin.

Product Details
Technical Data Sheet (pdf)

Product Details

Human (Human and Mouse sequences are identical, likely to interact with Mouse)
Antibody Type
Host Species
This monoclonal antibody was raised using a GST-fusion containing the complete N-terminal fragment of human PS2 (residues 1-87).
Tissue Culture Supernatant
Storage & Handling
Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody. For long-term storage, keep the antibody at -80°C.


Recommended Usage

Each lot of this antibody is quality control tested by immunohistochemical staining.

The optimal working dilution should be determined for each specific assay condition.
WB: 1:50
ICC: neat

Application Notes

This antibody is effective in immunoblotting and immunocytochemistry (ICC).

Application References

(PubMed link indicates BioLegend citation)
  1. Brunello L, et al. 2009. J. Cell Mol Med. 13:3358. (WB) PubMed
Product Citations
  1. Brunello L, et al. 2009. J Cell Mol Med. 13:3358-3369. PubMed
AB_2564781 (BioLegend Cat. No. 814201)

Antigen Details

Biology Area
Cell Biology, Neurodegeneration, Neuroscience, Protein Misfolding and Aggregation
Molecular Family
Gene ID
5664 View all products for this Gene ID
View information about Presenilin 2 on

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Go To Top Version: 2    Revision Date: 10.19.2017

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*These products may be covered by one or more Limited Use Label Licenses (see the BioLegend Catalog or our website, BioLegend products may not be transferred to third parties, resold, modified for resale, or used to manufacture commercial products, reverse engineer functionally similar materials, or to provide a service to third parties without written approval of BioLegend. By use of these products you accept the terms and conditions of all applicable Limited Use Label Licenses. Unless otherwise indicated, these products are for research use only and are not intended for human or animal diagnostic, therapeutic or commercial use.


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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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