- 58A (See other available formats)
- Regulatory Status
- Other Names
- MPZ, Myelin Protein Zero
- Mouse IgG2b, κ
- Ave. Rating
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- Product Citations
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Myelin protein zero (MPZ), is a membrane glycoprotein mainly expressed in the peripheral nervous system (PNS). It is the major structural component of the myelin sheath, and accounts for at least 50% of all proteins in the PNS. MPZ is expressed by Schewann cells. Mutations in MPZ have been associated with myelin deficiency, which may lead to neuropathies including charcot-Marie-Tooth and Dejerine-Sottas diseases.Product Details
- Human, Mouse, Rat
- Antibody Type
- Host Species
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 647 under optimal conditions.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
IHC-P - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry, a concentration range of 2.0 - 10 µg/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
* Alexa Fluor® 647 has a maximum emission of 668 nm when it is excited at 633 nm / 635 nm.
Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.
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- Excitation Laser
Red Laser (633 nm)
(PubMed link indicates BioLegend citation)
- Yoshimura K, et al. 1996. Neurosci Res. 25(1):41 (WB, IHC, ELISA)
AB_2814593 (BioLegend Cat. No. 862209)
AB_2814594 (BioLegend Cat. No. 862210)
- MPZ is a 248 amino acid protein with an apparent molecular mass of ~ 28 kD.
Tissue Distribution: Peripheral nervous system
Cellular Distribution: Plasma membrane, extracellular, endoplasmic reticulum, and lysosome
- MPZ is an adhesion molecule involved in the formation of myelin sheath in the peripheral nervous system.
- Forms homodimer and homotetramer
- Biology Area
- Neurodegeneration, Neuroscience Cell Markers
- Molecular Family
- Adhesion Molecules
- Antigen References
- Chiò A and Lauria G. 2016. Lancet Neurol. 15(1):12
- Brennan KM, et al. 2015. Neurosci Lett. 596:14
- Tazir M, et al. 2014. J Neurol Sci. 347(1-2):14
- Gene ID
- 4359 View all products for this Gene ID 17528 View all products for this Gene ID 24564 View all products for this Gene ID
- View information about Myelin Protein Zero on UniProt.org
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