- P87H10B9 (See other available formats)
- Other Names
- NPM, Nucleolar phosphoprotein B23, Nucleolar protein NO38, Numatrin
- Mouse IgG1, κ
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- Product Citations
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Nucleophosmin is a member of the nucleophosmin/nucleoplasmin family that shuttles between the nucleus and cytoplasm. This protein regulates the stability and transcriptional activity of p53 and acts as a molecular chaperone. It preferentially binds to denatured proteins and has been shown to stimulate DNA polymerase activity and control the duplication of centrosomes. The chaperone activity of nucleophosmin is regulated by protein kinase CK2 and promotes the release of denatured substrates from nucleophosmin. It is modified by phosphorylation on Thr199. This protein has been shown to bind to RNA and DNA and interact with nucleolar proteins including nucleolin, protein P120, HIV-1 Rev protein, and hepatitis delta antigens.Product Details
- Antibody Type
- Host Species
- Purified recombinant human nucleophosmin (2-265 a.a.) expressed in E. coli.
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 594 under optimal conditions.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
ICC - Quality tested
- Recommended Usage
Each lot of this antibody is quality control tested by immunocytochemistry. For immunocytochemistry, a concentration range of 0.2 - 1.0 μg/ml is recommended. It is recommended that the reagent be titrated for optimal performance for each application.
* Alexa Fluor® 594 has an excitation maximum of 590 nm, and a maximum emission of 617 nm.
Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.
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AB_2617022 (BioLegend Cat. No. 686803)
- 294 amino acids with a predicted molecular weight of 33 kD.
- Involved in ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF.
- NSUN2, SENP3, hepatitis delta virus S-HDAg, HTLV1 Rex protein, methylated form of RPS10, APEX1, NEK2, ROCK2 and BRCA2, RPGR, CENPW, EIF2AK2/PKR, CEBPA (isoform 4), and DDX31.
- Biology Area
- Cell Biology
- Molecular Family
- Antigen References
1. Szebeni A, et al. 2003. J. Biol. Chem. 278:9107.
2. Colombo E, et al. 2002. Nat. Cell Biol. 4:529.
3. Chan PK, et al. 1986. J. Biol. Chem. 261:14335.
- Gene ID
- 4869 View all products for this Gene ID
- View information about Nucleophosmin on UniProt.org
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