Oct4 in Mammalian ESC Pluripotency


Oct4 (also known as Oct-3) is a transcription factor whose expression is tightly linked to pluripotency in mammalian embryonic stem cells. It is highly expressed in ESCs and its expression decreases upon differentiation. Oct4 is a member of the POU family of transcription factors. In cooperation with other transcription factors like SOX2 and Nanog, it binds to genes to regulate transcriptional networks that regulate important functions like cell cycle control, anti-apoptotic genes, DNA repair, and chromatin structure and regulation.


Click on the poster below to view the interactive version.

 

Oct4 in Mammalian ESC Pluripotency

ProductsHere
Insert Note Here
Save Close Clear
Lab Timer
Tools
Login / Register
Forgot your password? Reset password?
Create an Account