- S16007D (See other available formats)
- Regulatory Status
- Other Names
- P2Y12, ADPG-R, BDPLT8, HORK3, P2T(AC), P2Y(12)R, P2Y(AC), P2Y(ADP), P2Y(cyc), P2Y12P2Y12 platelet ADP receptor, purinergic receptor P2RY12, purinergic receptor P2Y, G-protein coupled, 12
- Rat IgG2b, κ
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- Product Citations
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Purinergic Receptor P2Y (P2RY12) is a receptor for ADP and ATP coupled to G-proteins that inhibit the adenylyl cyclase second messenger system. P2RY12 is not activated by UDP and UTP. Required for normal platelet aggregation and blood coagulation. P2RY12 is a highly selective marker for microglia that specifically distinguishes these cells from other myeloid cells.Product Details
- Antibody Type
- Host Species
- Mouse P2RY12.
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- The antibody was purified by affinity chromatography.
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
IHC-P - Quality tested
FC - Verified
- Recommended Usage
Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry, a concentration range of 5.0 - 10 µg/ml is suggested. For flow cytometric staining. a concentration range of 0.5 - 5.0 µg/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
View the video of our collaborator discussing the importance of highly specific monoclonal antibodies for P2RY12 in Microglia research.
Learn more about the validation testing we performed on clone S16007D by watching our Scientific Poster Video.
- Additional Product Notes
View more applications data for this product in our Scientific Poster Library.
- Product Citations
AB_2650633 (BioLegend Cat. No. 848001)
AB_2650634 (BioLegend Cat. No. 848002)
- P2RY12 is a 347 amino acid protein with a molecular mass of 39.8 kD.
Tissue distribution: platelets, brain (microglia), lung, appendix, pituitary and adrenal glands.
Cellular distribution: cell membrane and cytosol.
- G-protein coupled receptor that inhibits the adenylyl cyclase second messenger system.
- ADP and ATP.
- Cell Type
- Microglia, Platelets
- Biology Area
- Cell Biology, Immunology, Innate Immunity, Neuroscience, Neuroscience Cell Markers
- Molecular Family
- GPCR, Purinergic Receptors
- Antigen References
1. Orr AG, et al. 2009. Nat. Neurosci. 12(7):872-8.
- Gene ID
- 70839 View all products for this Gene ID
- View information about P2RY12 on UniProt.org
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