BioLegend at ASCB 2017

 

We look forward to seeing you at the 2017 ASCB | Embo Meeting at Booth #330. Come by our booth to learn about our newest products that support research in cell structure, cell signaling, epigenetics, cell cycle, and more. These reagents are multi-purpose, as they are useful in several applications, including western blotting, flow cytometry, and immunohistochemistry.

And, be sure to attend our tech talk where we showcase our cell biology reagents. You’ll learn about bone cell differentiation and cancer and have a chance at a $50 Amazon gift card.

 
  Bone Cell Differentation and Bone Cancer
  Presenter: Mohar Chattopadhyay, Ph.D., Product Manager
  Sunday, December 3 | 10:35 - 11:45AM | Theater 2
  Tech Talk Drawing: All attendees will be entered to win a
  $50 Amazon Card!

Cell signaling is the transmission and integration of signals from the outside to the inside of the cell. These signals exert a specific effect on the cell, and the intracellular signaling pathways amplify the message using a network of enzymes and proteins. Since the ability of cells to correctly process signals is critical for their survival, errors in cell signaling typically causes diseases such as cancer, diabetes, and autoimmunity.

Featured Products:
ZAP70 Phospho (Tyr319)/Syk Phospho (Tyr352)
BTK Phospho (Tyr223)
STAT1 Phospho (Ser727)
Syk
PTEN
LCK Phospho (Tyr505)

Find more reagents for cell signaling...


Purified anti-ZAP70 Phospho (Tyr493) Antibody
Jurkat cells treated without (Lane 1) or with (lane 2) 2 mM H202 for 3 min were probed with purified anti-ZAP70 Phospho (Tyr493) antibody (Clone A16043C). Equal ZAP70 loading was confirmed using purified anti-ZAP70 antibody.
 



MitoSpy™ Red CMXRos
Jurkat cells were treated with LEAF™ purified anti-human CD95, and stained with MitoSpy™ Red CMXRos following by staining with Alexa Fluor® 488 Annexin V.

Cellular organelles are membrane bound structures within a cell that have unique cellular functions. BioLegend offers a number of products to detect sub-cellular localization of proteins through organelle-selective probes or antibodies that can be used for live or fixed-cell imaging, as well as for western blot and flow cytometry.

Featured Products:
Centrin-2
Nestin
Aurora B
Mitospy™
Pan cytokeratin
Nuclear pore complex

Visit our microscopy reagents page...
Learn more about our chemical probes...

In eukaryotic cells, DNA is assembled into chromatin with repeating units of nucleosomes. This complex forms the basis of the epigenetics landscape and is a dynamic system that undergoes multiple post-translational modifications (PTMs) and interacts with several regulatory proteins including transcription factors to control gene expression. This in turn, can dictate gene expression patterns in a cell by regulating the relative accessibility of transcription factors and the transcriptional machinery to the DNA.

Featured Products:
ChIP Kit
Go-ChIP-Grade™ Antibodies
HDAC
STAT
IRF
RUNX3

Find more reagents for epigenetics...


Go-ChIP-Grade™ Purified anti-STAT1 Phospho (Ser727) Antibody
ChIP was performed with chromatin samples from HeLa cells with either A) Go-ChIP-Grade™ Purified anti-Histone H4 Trimethyl (Lys20) Antibody (clone 6F8-D9), B) equal amount of matched isotype Control Antibody (clone MOPC-21), or C) competitor's ChIP-grade Purified anti-Histone H4 Trimethyl (Lys20) Antibody and D) equal amount of matched Isotype Control Antibody as recommended by the manufacturer. The enriched DNA was purified and quantified by real-time qPCR using primers targeting human MYOD gene regions.



Purified anti-Aurora B Antibody
HeLa cells were intracellularly stained with anti-Aurora B antibody (clone W16153A) followed by Alexa Fluor® 594 (red) conjugated goat anti-rat IgG (Cat no. 405422). Nuclei were counterstained with DAPI (blue). The images displayed HeLa cells at different phases of mitosis.

The cell cycle is a series of precisely timed and carefully regulated stages in a cell that consists of cell growth, DNA replication, distribution of the chromosomes to daughter cells, and cell division. A large number of proteins are involved in the complex machinery that regulate and maintain the cell cycle such as cyclins, cyclin-dependent kinases, tumor suppressors, and checkpoint proteins. Cells with irreparable DNA lesions undergo permanent cell-cycle arrest or apoptosis.

Featured Products:
H2A.X Phospho (Ser139)
p53
Cyclin D2
DNA-PKcs Phospho (Thr2609)
CDKN1A
Phase Flow™ BrdU Kits

Find more reagents to study the cell cycle...
     
Description
Go-ChIP-Grade™ Protein G Enzymatic Kit
Cell Bio Antibody Sampler Kits
LDH-Cytox™ Assay Kit
KO and KD Validated Cell Biology Antibodies
Coming Soon: Western-Ready™ ECL Substrate Kit
     
Swing by the booth to pick up our latest brochures, which offer comprehensive product listings, detailed testing data, and more. Or request copies to be sent to you with the button below.

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